摘要
目的：为探讨Ｆａｓ、Ｂａｘ基因在胃癌发生过程中的意义。方法：用免疫组化ＡＢＣ方法检测了４８例胃腺癌组织，７４例非癌胃粘膜组织。结果：重度不典型增生组织及癌组织中Ｆａｓ蛋白表达率分别为３７５％、４５８％较正常胃粘膜上皮的８２３％显著下降（Ｐ＜００５），轻、重不典型增生组织及癌组织中Ｂａｘ蛋白表达率为４２８％，５００％，４３６％较正常胃粘膜上皮的８８２％显著下降（Ｐ＜００５）。中、高分化胃癌Ｆａｓ、Ｂａｘ蛋白阳性表达率显著高于低分化癌（Ｐ＜００５）。并且Ｆａｓ与Ｂａｘ在组织中的表达呈相关性（Ｐ＜００５）。结论：Ｆａｓ、Ｂａｘ蛋白表达变化发生在胃粘膜癌变的早期阶段，并可能与癌的进展密切相关，Ｆａｓ与Ｂａｘ在胃癌发生发展中有显著的相关性。
Objective: To study the role of Fas and Bax gene in the carcinogenesis of gastric adenocarcinoma.Methods: The expression of Fas and Bax protein in the cancer tissues from 48 patients and nocarcirous tissues from 74 patients were detected with immunohistochemical ABC method.Results: The expression of Fas protein in severe hyperplasia mucosa and cancer tissue(37.5%、45.8% respectively) decreased significantly as compared to that in normal epithelia (82.3% P <0.05) ;the expression of Bax protein in maderate hyperplasia mucosa and severe hyperplasia mucosa and cancer tissue (42.8%、 50.0% 、43.6% respectively) were significantly lower than that in nomal epithelia(88.2%)( P <0.05).The positive rates of Fas and Bax protein in cancers of grade Ⅰ、Ⅱ and Ⅲ decreased gradually.The cancer of grade Ⅲ showed a significant lower expression of Fas and Bax protein than that in cancer of grade Ⅰ and Ⅱ ( P <0.05) Conclusion: The alteration of Fas and Bax gene is an early event in the carcinogenesis of gastric adencarcinoma and may be closely related to the progress of the cancer.
出处
《河南医学研究》
CAS
1999年第1期21-23,共3页
Henan Medical Research
