摘要
目的:评价组织工程血管支架材料的性能和应用前景。方法:以"组织工程,组织工程血管,干细胞,细胞因子,支架材料为中文关键词;以:"tissue engineering,tissue engineering blood vessel,intravascular stent"为英文关键词,采用计算机检索1993-01/2009-10相关文章。纳入与有关生物材料与组织工程血管相关的文章;排除重复研究或Meta分析类文章。以30篇文献为主重点讨论了组织工程血管材料的种类及其性能。结果:血管脱细胞基质可作为一种较理想的支架材料应用于血管组织工程。基于纤维蛋白制成的支架,不但具有理想的生物相容性、生物降解性和较高的亲和性,而且能促进血管生成、组织修复。明胶无抗原性,生物相容性好,可完全生物降解,可以实现支架自身的"血管化"。天然生物材料和合成高分子材料都存在一定不足,将两者按照一定的方法组合构建成一种复合基质,发挥两者各自的优势构建出性能良好的组织工程化血管。纳米修饰技术有望被应用于下一代组织工程化血管移植。结论:组织工程血管近年来发展迅速,到目前为止,还没有发现一种很理想的血管支架材料。虽然现在天然生物材料成为研究的热点,但是物理机械性能并不能很好地符合支架要求,这就迫切需要新材料的出现,来更好的满足组织化血管支架的要求,达到修复和重建的目的。
OBJECTIVE：To evaluate the characteristics and application prospect of tissue-engineered blood vessel stent materials.METHODS：Using＂tissue engineering,tissue engineering blood vessel,intravascular stent＂both in Chinese and English as key words to search documents published between January 1993 and October 2009.Literatures concerning biomaterials and tissue engineered blood vessel were included.Repetitive research or Meta analysis was excluded.After selection,30 documents were included to discuss the kinds and characteristics of tissue-engineered blood vessel materials.RESULTS：Cellular tissue matrix is a kind of ideal material for intravascular engineering,which had widely applied in tissue-engineered stent.The fibrin-based stents are characterized by good biocompatibility,biodegradation,compatibility,as well as promote vascularization and tissue repair.Gelatin can implement its own＂vascularization＂due to less antigenicity and can be fully biodegraded.Accordingly,both the natural biomaterials and synthetic polymeric material have certain limitations,thus,the combination of these two materials would construct a tissue-engineered blood vessel stent that has good characteristics.Nano-modified technology is hopeful to be applied in the future transplantation of tissue-engineered blood vessel stent.CONCLUSION：The tissue-engineered blood vessel developed rapidly in these years.However,as yet,there is not an ideal intravascular stent material.The natural biomaterials arose more attention,but the mechanical function of which is far from the stent requirement.Thus,to reach the aims of repair and reconstruction,new materials are the urgent need in tissue-engineered intravascular stent.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第16期2958-2962,共5页
Journal of Clinical Rehabilitative Tissue Engineering Research
