摘要
目的:探讨胰岛素样生长因子-1(Insulin-like growth factor-1,IGF-1)在糖尿病下肢血管病变中的预测价值。方法:对138例2型糖尿病患者进行下肢血管病变的检查,以DSA结果为下肢血管病变诊断的金标准。ELISA法测IGF-I水平,应用ROC及评价预测价值,以Youden指数确定诊断界点。结果:随着下肢血管狭窄程度的增高,患者血清IGF-1水平逐渐增高(P<0.05)。IGF-1水平和ABI(r=0.761,P=0.014)、彩超(r=0.796,P=0.021)及DSA检查(r=0.856,P=0.008)的血管狭窄程度均呈正相关。IGF-1对DM下肢血管病变具有很好的预测价值(AUC=0.734,P=0.001),95%的CI为0.621～0.846。诊断界点为180.0ng/mL时,其诊断效能最高。结论:IGF-1对糖尿病下肢血管病变中有较好的预测价值。
Objective：To investigate the value of insulin-like growth factor-1（IGF-1） in diabetes for predicting lower limb vascular disease.Methods：138 patients with type 2 diabetes were checked with lower extremity vascular disease in which DSA results as gold diagnostic standard.ELISA were used to measure IGF-I levels.The predictive value was evaluated by ROC and Youden index for cut-off point.Results：With the extent of lower extremity vascular stenosis increased,serum levels of IGF-1 was gradually increased（P 0.05）.IGF-1 levels was positively correlated with ABI（r=0.761,P=0.014） for the degree of vascular stenosis as well as color Doppler ultrasound（r =0.796,P=0.021）,and DSA examination（r= 0.856,P=0.008）.IGF-1 has a very good predictive value for DM lower extremity vascular disease（AUC= 0.734,P =0.001）,95% of the CI,0.621～0.846.The cut-off point was 180.0 ng /mL.Conclusion：IGF-1 has a good predictive value for diabetic lower extremity vascular disease.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2010年第3期430-432,共3页
Journal of Chongqing Medical University
关键词
糖尿病
下肢血管病变
胰岛素样生长因子-1
诊断
Diabetes mellitus
Lower limb vascular disease
Insulin-like growth factor-1
Diagnosis
