摘要
目的观察消旋卡多曲颗粒辅助治疗儿童轮状病毒肠炎的疗效及不良反应。方法轮状病毒肠炎患儿100例按数字表法随机分为A组和B组各50例，B组给予常规治疗和蒙脱石散治疗，A组在B组治疗基础上加服消旋卡多曲颗粒，1．5mg·kg^-1·次^-1，3次／d，疗程5～7d，观察两组临床治疗效果及不良反应发生情况。结果A组呕吐改善时间（1．5±0．4）d、退热时间（1．3±0．3）d、腹泻改善时间（1．7±0．4）d较B组的（2．4±0．3）d、（2．3±0．4）d、（2．9±0．1）d明显缩短（t=2．245、2．298、2．301，均P〈0．05）；治疗3d后A组总有效率92．0％，高于B组的（74．0％）（χ^2=3．987，P〈0．05）；A组平均治愈时间（5．5±0．9）d低于B组的（7．0±1．1）d（t=7．17，P〈0．01）；两组均未发生严重不良反应。结论消旋卡多曲辅助治疗儿童轮状病毒肠炎可提高临床治疗效果，不良反应少。
Objective To investigate the curative effect of racecadotril granules on acute rotaviral enteritis in infants. Methods 100 infants with acute rotaviral enteritis were divided into combined treatment group（group A：50） cases and smecta group（ B group ：50 cases） ;Group B was given to basis of conventional therapy, but Group A received conventional therapy combined with clothing racecadotril particles. The efficacy and adverse reactions were observed. Results The time of improvement of vomiting, fever and diarrhea in A group was signilqcantly shorter than the B group（t =2. 245,2. 298,2. 301, all P 〈 0. 05 ） ; The total effective rate 92.0% in A group were higher than the B group 74.0% after treatment 3d （ χ^2 = 3. 987, P 〈 0. 05 ）. The average course of treatment in A group （5.5 ±0. 9 ） d was lower than the B group （7.0 ±1.1 ） d （ t = 7.17, P 〈 0. 01 ）. Conclusion Racecadotril is an effective and safe drug in treating rotaviral enteritis in infants.
出处
《中国基层医药》
CAS
2010年第8期1043-1044,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
轮状病毒感染
消旋卡多曲
儿童
Rotavirus infections
Racecadotril graules
Child
