摘要
目的:了解BiPAP呼吸机对治疗慢性阻塞性肺疾病(chronic obstructive pulmonary diseases,COPD)合并Ⅱ型呼吸衰竭患者的疗效。方法:62例COPD合并轻、中度Ⅱ型呼吸衰竭(pH7.25～7.35)的住院患者随机被分为治疗组(30例)和对照组(32例),治疗组在常规治疗的基础上连续使用BiPAP呼吸机3d(2次/d,4h/次),对照组仅给以常规治疗。观察两组患者治疗前后血气分析、呼吸频率、心率、Borg评分、肺功能变化以及气管插管率和住院天数。结果:治疗3d后,治疗组pH和PaCO2的改善较对照组更明显(P<0.05)。治疗组气管插管率明显低于对照组(P<0.05);pH7.31～7.35患者中治疗组气管插管率与对照组类似(P>0.05),pH7.25～7.30患者中治疗组气管插管率明显低于对照组(P<0.01)。治疗组住院天数少于对照组(P<0.05)。结论:BiPAP呼吸机能更好地改善COPD合并轻、中度Ⅱ型呼吸衰竭患者的pH和PaCO2,尤其降低中度呼吸衰竭患者气管插管率,缩短住院时间。
Objective To determine the of BiPAP ventilator in treating chronic obstructive pulmonary diseases （COPD） combined with respiratory failure. Methods A total of 62 COPD patients combined with mild to moderate respiratory failure Type Ⅱ （pH 7.25-7.35） were randomly divided into control group, received routine therapy, and BiPAP group, received noninvasive ventilation by BiPAP ventilator （2 times per day, 4 h per time） on the basis of routine therapy. The blood gas analysis, heart rate, respiratory rate, Borg scale, and pulmonary function before and after treatment as well as intubation rate and days of hospitalization were determined. Results After the 3 d treatment, arterial pH and PaCO2 improved in both groups, but changes were more profound in the BiPAP group （P0. 05）. The intubation rate was lower in the BiPAP group than that in the control group （P0.05）. In patients with pH 7.31-7.35, these percentages were similar （P0.05）. In patients with pH 7.25-7.30, the intubation rate was lower in the BiPAP group than that in the control group （P0.01）. The duration in hospital was shorter in the BiPAP group than that in the control group （P0.05）. Conclusion The use of BiPAP ventilator could improve the parameters of arterial pH and PaCO2 in COPD patients combined with mild to moderate respiratory failure Type Ⅱ, and particularly reduce the need for intubation and the duration in hospital for the patients with moderate respiratory failure Type Ⅱ.
出处
《国际病理科学与临床杂志》
CAS
2010年第2期143-146,共4页
Journal of International Pathology and Clinical Medicine
关键词
无创通气
慢性阻塞性肺疾病
呼吸衰竭
non-invasive ventilation
chronic obstructive pulmonary diseases
respiratory failure
