摘要
目的比较紫杉醇脂质体与普通紫杉醇治疗老年非小细胞肺癌的疗效及毒副反应。方法 68例老年非小细胞肺癌患者随机分为试验组和对照组。试验组33例给予紫杉醇脂质体135mg/m2,对照组35例给予紫杉醇135mg/m2,每21天为一周期,共2周期。观察两组的疗效及毒副反应情况。结果两组在疗效及血液学毒性、消化道反应的差异无统计学意义,但因溶媒产生的过敏反应方面,试验组明显低于对照组,有统计学意义。结论紫杉醇脂质体治疗老年非小细胞肺癌效果良好,两种紫杉醇疗效相当,但紫杉醇脂质体的过敏反应明显低于紫杉醇。
Objective To analyze the effects and adverse reactions of paclitaxel liposome in the treatment of elderly patients with non-small cell lung cancer compared with traditional taxol.Methods 68 elderly NSCLC patients were randomly divided into two groups：the test group（33 cases were given paclitaxel liposome at 135 mg/m2 each session） and the control group（35 cases were given paclitaxel at 135 mg/m2 each session）.The effects and adverse reactions of the two groups was evaluated after two cycles（3 weeks per cycle）.Results There was no significant difference between two groups in curative effects and hematological toxicity（P0.05）.The test group was better than the control group in preventing hypersensitive reactions and the significant differences were found between them（P0.05）.Conclusion Paclitaxel liposome in the treatment of elderly NSCLC patients,being similarily effective as taxol,can significantly lower the incidence of serious hypersensitive reactions.
出处
《中国实用医药》
2010年第14期43-44,共2页
China Practical Medicine
