摘要
目的：动态观察一氧化氮（NO）供体硝酸甘油对妊高征（PIH）的心功能影响。方法：应用CF型心血管功能监测仪分别测定静滴硝酸甘油前及用药后心功能参数，并用胎心监护仪监测胎心率。结果：用药后半小时，每搏血量（SV）、每搏功能指数（SWI）、左室射血分数（EF）、心肌收缩力（MCF）增加，平均动脉压（MAP）、总血管阻抗（TPR）、心舒末容量指数（EDVI）减少；停药后2，小时药物作用显著减弱（P＜0．05），心输出量（CO）、心率（HR）用药后略有增加，但无统计学意义（P＞0．05）。胎心率未发现异常改变。结论：硝酸甘油不仅能有效地降低PIH的血压，改善心功能，而且避免了某些降压药物的副作用，如：HR增快、CO下降、MVO增加等，同时对胎儿无不良影响。
The aim of this study was to observe the effect on the cadiac function of patients with pregnancy induced hypertension (PIH) with the treatment of nitroglycerin. Method: The paraments of cardiac function were analyzed with the monitor before and after treatment. Fetal heart rate was the recorded. Result: Thirty minutes after nitroglycerin administration, stroke volume (SV), stroke work index (WTI), ejection fraction (EF), myocardial contractive force (MCF) increased significantly (P< 0. 05), mean arterial pressure (MAP), total Peripheral resistance (TPR), end diastolic volume index (EDVI) decreaced significantly (P < 0. 05 ). When we stop treatment, the effect of nirtoglycerin decreased significantly after two hours no significant changes were found in heart rate (HR) and cardiac output (CO) after treatment (P > 0. 03 ). Fetal heart rate was not abnormal. Conclusion: Nitroglycerin can not only reduce bind pressure of PIH, improve cardiac function, but also avoid the side effects of other medicines and it has not harmful effect on fetal.
出处
《中国优生与遗传杂志》
1999年第1期62-63,共2页
Chinese Journal of Birth Health & Heredity
关键词
心功能
硝酸甘油
妊娠高血压
一氧化氮
Pregnancy induced hypertension, Cardiacfunction, Nitroglycerin.
