摘要
142例平衡结构畸变的分析结果显示，妇产科临床重排断裂除较多累及近端着丝粒染色体14、15、22号外，7、8号染色体受累频率也显著性偏高。而2、4、5、6号染色体不仅断裂点的分布频率显著性偏低，而且有关平衡结构畸变个体的表型异常显著性增高。分析同时表明，重排断裂在3种不同G显带上的分布是非随机的，但在脆性位点是随机的。重排断裂点的这种分布规律既可能与染色体的内在分子结构有关，也可能与选择机制相联系。
The distribution of rearranged breakpoints of 142 balanced chromoslomal abnormalities in obstetric and gynecologic clinic was analyed. The results showed that in the acrocentric chromosome 14, 15, 22 and chromosome 7 and 8, there are significantly more breakages than the expects (P < 0. 01 ), while in chromosome 2, 4, 5 and 6, there are significantly fewer brmkages (P< 0.05 ). The ratio of abnormal phenotype in the tients with the chromosomal rearragnments which has fewer breadage is sighficantly higher than that in the rest patients (P <0.05). It was ho found that the distribution of the breakpoints in three different G-bandings is not random but in fragile sites. Such distributions of rearranged breakpoints may associatewith the molecular structure of the chromosome or the mecha nism of the mecha
出处
《中国优生与遗传杂志》
1999年第1期36-37,共2页
Chinese Journal of Birth Health & Heredity
关键词
妇产科
断裂点
染色体畸变
平衡结构畸变
Chromosome, Balanced structural abnormality,Breakpoint, Phenotype, Fragile site
