摘要
研究了骨架镍催化下，芳香硝基化合物和醇进行还原烷基化合成Ｎ－单烷基芳胺衍生物时，苯环上取代基位置和性质以及作为烷化剂的醇的结构变化对Ｎ－烷化反应的作用；证明苯环上给电子基促进反应进行，吸电子基则减缓还原烷基化．该工艺适用于除Ｎ－甲基化外的其他Ｎ－直链烷基化．
? The reduction alkylation of nitrobenzene compounds with various aliphatic alcohols in the presence of Raney nickel as a catalyst is studied. The relative positions of the substituents with respect to the nitro group on benzene ring and the configuration of alcohol play a major role on the yields of the product. The bulky group at ortho position of nitro group leads to giving lower yields due to steric hindrance, while, the electron donor group would tend to accelerate the reaction, but an adverse effect is observed for the electron acceptor groups. This current technique could be used for preparing N mono alkyl( n ) aryl amines, except methylation.
出处
《大连理工大学学报》
CAS
CSCD
北大核心
1999年第1期60-65,共6页
Journal of Dalian University of Technology
关键词
烷基化
醇
取代基
苯环
还原
烷基芳胺
烷化剂
alkylation
alcohols
substituent effect/aromatic nitro compounds
Raney nickel
