摘要
目的探讨脂蛋白脂酶(LPL)在子痫前期血脂代谢中的临床意义。方法回顾性分析310例重度子痫前期孕妇(子痫前期组)和300例健康晚孕妇女(晚孕组)、300例健康未孕育龄妇女(未孕组)的血脂代谢情况;检测26例子痫前期组、30例晚孕组和30例未孕组血LPL、TG、HDL浓度。结果子痫前期组存在显著的高TG、低HDL血脂代谢异常,LPL与TG呈负相关、与HDL呈正相关。结论子痫前期存在显著的高血脂异常代谢,LPL可能通过参与异常血脂代谢而导致子痫前期发病。
Objective： To evaluate the association of lipoprotein lipase with lipid profile in preeelamptie pregnancies. Methods： To retrospectively analyze lipid/lipoprotein profile of 310 cases of severe preeclampsia and 300 normal pregnant women and 300 un - pregnant women. Serum lipoprotein lipase （LPL）, triglyeeride （TG） and high density lipoprotein （HDL） were evaluated and the levels of those were compared between 26 pathologic and 60 control groups. Results ： The highest TG levels and the lower HDL levels were found in preeelampsia. Negative correlation between LPL and TG, and positive correlation between LPL and HDL were presented in this group. Conclusion： LPL possibly participates in the pathogenesis of preeclampsia through adjusting lipid metabolism.
出处
《中国优生与遗传杂志》
2010年第5期48-49,71,共3页
Chinese Journal of Birth Health & Heredity
关键词
子痫前期
血脂
脂蛋白脂酶
Preeclampsia
Serum lipid
Lipoprotein lipase
