摘要
目的了解和掌握北京市人群对甲型H1N1流感的免疫水平。方法在2009年11月27日至12月23日从医院患者（排除感染科和呼吸科）、血液中心志愿者和体检中心健康体检者中随机选取调查对象进行问卷调查，并采集血清标本进行甲型H1N1流感病毒血凝抑制（HI）抗体检测。结果共选取调查对象856名，其中127名（14．8％）调查对象体内甲型H1N1流感病毒HI抗体为阳性。0～5岁、6～17岁、18～55岁、≥56岁年龄组HI抗体阳性率分别为14．5％、19．4％、17．4％和8．0％（P=0．009）。不同性别HI抗体阳性率差异无统计学意义（P=0．693）。人群血清HI抗体年龄加权阳性率为15．8％。多因素logistic回归分析显示，年龄、出现过急性呼吸道症状以及接种甲型H1N1流感疫苗与HI抗体阳性呈显著性相关。结论北京市已经有超过15％的人群具有甲型H1N1流感保护性抗体，普通人群中已经建立一定的免疫屏障。
Objective To investigate the immunological level against influenza A （H1N1） 2009 in Beijing and provide evidence to evaluate the developing trend of the disease. Methods Between Nov. 27,2009 and Dec. 23,2009, subjects were randomly selected from patients in hospitals （infectious and respiratory diseases related departments were excluded）, volunteers in blood donation center and healthy subjects attending the physical examination center. Questionnaire survey was conducted and serum samples were collected to detect the hemagglutination-inhibition （HI） antibody against influenza A （H1N1） 2009 virus. Results 856 subjects participated in this survey, and 127 showed positive HI antibody to this pandemic virus. The proportions of sero-positivity among 0-5 , 6-17, 18-55, ≥56 year olds were 14.5%, 19.4%, 17.4% and 8.0% respectively （P=0.009）. There was no significant difference in the sero-positivity between males and females （P=0.693）. The age-adjusted positive rate was 15.8% in the population of Beijing. By multivariate logistic regression analysis, factors as age, acute respiratory symptoms and the rate of pandemic （H1N1） 2009 vaccination were significantly associated with sero-positivity of HI antibody to the influenza A （H1N1） 2009 virus. Conclusion Above 15% of the population in Beijing showed protective antibody against influenza A （H1N1） 2009 virus, indicating the development of immunological barrier to this disease had been formed, to some extent.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2010年第5期485-488,共4页
Chinese Journal of Epidemiology
基金
国家高技术研究发展计划（863计划）（2008AA022416）
“十一五”国家科技支撑计划（2009ZX10004-315）
北京市自然科学基金（7082047）
北京市科委科研院所重点研究项目
