摘要
目的比较肺癌化疗过程中血小板平均体积(MPV)、血小板计数(PLT)、白细胞计数(WBC)的变化,探讨MPV是否可以作为骨髓造血功能恢复的早期指标。方法用Sysmex XE-2100全自动血液分析仪测定MPV、PLT、WBC等指标,建立健康人群MPV生物参考区间,比较不同病理类型肺癌相关指标,并对156例肺癌病人化疗过程中MPV等指标的变化进行分析。结果确定本实验室MPV生物参考区间为(10.5±2.3)fl;腺癌的MPV稍大于其他类型肺癌,但差异无显著性(F=3.56,P>0.05);肺癌化疗过程中MPV提示骨髓造血功能恢复的时间(11～15d)要早于PLT、WBC(16～20d)。结论MPV可作为肺癌化疗后骨髓功能恢复的比较敏感的早期指标。
Objective To compare the change of mean platelet volumes（MPV）,platelet count（PLT）and white blood cell count（WBC）in patients with lung cancer during chemotherapy,and to investigate the possibility of using MPV as an early index in predi-cating hematopoietic recovery.Methods MPV,PLT and WBC were measured by using Sysmex XE-2100 hematology analyzer;Biolog-ical reference intervals of MPV in healthy populations were established;The related index of different pathological clasificated lung cancer were compared;And the changes of MPV,PLT and WBC during chemotherapy in 156 patients with lung cancer were analyzed. Results Biological reference intervals of MPV in our laboratory was defined as（10.5±2.3）fl;MPV in adenocarcinoma is slightly bigger than the other types lung cancer,but the difference is not significant（F=3.56,P0.05）;MPV is an earlier parameter than PLT and WBC in predicating hematopoietic recovery during chemotherapy（11～15 days vs 16～20 days after chemotherapy）.Conclusion MPV might be used as a sensitive predicative parameter for early bone marrow hematopoietic recovery during lung cancer chemotherapy.
出处
《江西医药》
CAS
2010年第4期307-309,共3页
Jiangxi Medical Journal
关键词
肺癌
平均血小板体积
化疗
lung cancer
chemotherapy
mean platelet volume
