摘要
DNA嵌插剂是一类以DNA为靶向并能与之形成复合物的多环芳香族小分子化合物。目前数个DNA嵌插剂开发用于卵巢癌、乳腺癌及急性白血病等肿瘤的治疗,处于各临床研发阶段的品种不少。DNA嵌插剂可通过平面芳香环系统插入DNA碱基对之间,造成DNA构象变化,影响其生理功能,达到抗肿瘤效果。本文综述多种DNA嵌插剂及其相关研究进展。
DNA-intercalators are small molecules that insert perpendicularly into DNA without forming covalent bonds. Several intercalators are used for the treatment of ovarian and breast cancer as well as acute leukemia, while many others are in different phases of clinical trials. The intercalators influence the physiologic function through the insertion of planar aromatic rings between DNA base pairs, which results in a conformational change of DNA. This review discusses the research progress of DNA-intercalators.
出处
《世界临床药物》
CAS
2010年第5期299-305,共7页
World Clinical Drug
基金
"重大新药创制"科技重大专项(2009ZX09301-007)
