摘要
目的了解广东省中山地区儿童呼吸道感染肺炎链球菌对常用抗菌药物的敏感性。以便有效指导临床合理用药和预防感染。方法采用纸片扩散法和E试验法,检测2008—2009年间在中山市博爱医院儿科就诊的年龄为1个月～6岁呼吸道感染儿童鼻咽分泌物、痰液培养分离的肺炎链球菌对常用抗菌药物的敏感性。结果从5 636例呼吸道感染儿童鼻咽部、痰液分离出肺炎链球菌共310株。肺炎链球菌对青霉素的不敏感率为78.0%,耐药率为0;对头孢曲松的敏感率为90.7%,中介为9.3%,耐药率为0;对常用抗菌药物耐药率分别为红霉素95.5%、克林霉素90.4%、四环素70.6%、磺胺甲口恶唑-甲氧苄啶85.3%、氯霉素6.3%、利福平0.7%和氧氟沙星0.3%,未检出对利奈唑胺和万古霉素耐药的菌株。结论本次调查结果显示,中山地区儿童感染肺炎链球菌对青霉素不敏感率已处于全国较高水平,对红霉素、克林霉素的耐药率都在90%以上,已不能作为治疗肺炎链球菌感染的经验用药。中山地区儿童肺炎链球菌对抗菌药物的耐药状况已很严峻,必须加强监测,及时调整经验用药方案和公共卫生策略。
Objective To investigate the antimicrobial susceptibility of S.pneumoniae isolated from children in Guangdong Zhongshan area between 2008 and 2009.Methods From 2008 to 2009,efforts were made to isolate S.pneumoniae from throat swab and sputum samples with respiratory infection in children of 1 month to 6 years old treated in Zhongshan Boai Hospital.Kirby-Bauer disc diffusion and E-test were conducted to test the antimicrobial susceptibility of these clinical isolates.Results Totally 310 strains of S.pneumoniae were isolated from throat swab and sputum.The prevalence of S.pneumoniae nonsusceptible to penicillin was 78.0%.The prevalence of penicillin-resistant S.pneumoniae was 0%.About 90.7% of the isolates were susceptible to ceftriaxone,9.3% intermediate.The resistance of S.pneumoniae to the commonly used antibiotic was: erythromycin 95.5%,clindamycin 90.4%,tetracycline 70.6%,chloramphenicol 6.3%,ofloxacin 0.3%,sulphamethoxazole-trimethoprim 85.3%,and rifampicin 0.7%.No linezolid or vancomycin resistant strain was found.Conclusions These data indicate that penicillin non-susceptible S.pneumoniae is highly prevalent in Zhongshan area.More than 90% of the isolates were resistant to erythromycin or clindamycin.These antibiotics can not be used as the empirical therapy for S.pneumoniae any more.Ongoing surveillance of the resistance in the isolates of S.pneumoniae is necessary for rational antibiotic therapy.
出处
《中国感染与化疗杂志》
CAS
2010年第1期49-52,共4页
Chinese Journal of Infection and Chemotherapy
关键词
肺炎链球菌
耐药性
儿童
Streptococcus pneumoniae
resistance
child
