摘要
甲基脲和氰乙酸乙酯在乙醇钠中缩合环化得到6-氨基尿嘧啶钠盐,钠盐酸化得6-氨基-1-甲基-2,4-(1H,3H)嘧啶二酮,再与亚硝酸盐亲电加成得到5-亚硝基-6-氨基-1-甲基-2,4-(1H,3H)嘧啶二酮,最后经连二亚硫酸钠还原得到5,6-二氨基-1-甲基-2,4-(1H,3H)嘧啶二酮,总收率为91.6%,其结构经1HNMR和IR表征。
Methylurea and ethyl eyanoaeetate were reacted under catalysis of ethanol sodium to give sodium 6- amino uracil, followed by acidification to form 6--amino-1-methyl-2,4 -（1H, 3H） pyrimidine dione. The later was further converted to 5,6-diamino-1-methyl-2,4（1H, 3H）-pyrimidinedione in two steps. The process afforeded the title compound in 91.6% overall yield, which was confirmed with 1H NMR, IR and elemental analysis.
出处
《精细化工中间体》
CAS
2010年第2期51-53,共3页
Fine Chemical Intermediates
