摘要
目的:探讨Caspase-9在肝硬化门静脉高压巨脾中的表达及对其形成的作用机制。方法:采用免疫组织化学SP法测定50例肝硬化门静脉高压患者巨脾和15例正常人外伤脾脏组织中Caspase-9的表达情况。结果:Caspase-9在外伤脾脏及巨脾组织中阳性表达率分别为26.7%和76.0%,差异有统计学意义(P<0.05)。Caspase-9阳性表达与肝功能Child分级及巨脾病理分级均呈正相关(r=0.834,P<0.05)。结论:Caspase-9参与了肝硬化门静脉高压中脾肿大及脾功能亢进的发生、发展过程。
Objective： To investigate the role of expression of Caspase-9 in megalosplenia of cirrhotic portal hypertension. Methods： Using SP immunohistochemistry method to examine theexpression of Caspase-9 in the specimens of 50 cases of megalosplenia with cirrhotic portal hypertension and 15 cases of traumatic spleen of normal man. Results： The Caspase-9 positive rates in the traumatic spleen and megaloplenia were 26.7% and 76.0%, respectively. There was a significant difference between the groups（P〈0.05）. There was positive correlation between the expression of Caspase-9 and Child types of liver function and cirrhotic splenic types （P〈0.05）. Conclusion： Caspase-9 might participate in the occurrence and development of splenic enlargement and hypersplenism in the cirrhotic portal hypertension.
出处
《中国现代普通外科进展》
CAS
2010年第2期121-124,共4页
Chinese Journal of Current Advances in General Surgery
