摘要
目的探讨高频超声对动脉粥样硬化性脑梗死(ATCI)患者动脉斑块的评价作用。方法68例ATCI患者随机分为常规治疗(A)组和氟伐他汀治疗(B)组(常规治疗基础上,每晚口服氟伐他汀40mg);于治疗前及治疗后3个月用高频超声检测患者颈动脉斑块指数、内膜中层厚度(IMT)及收缩峰期血流速度(PSV)、舒张末期血流速度(EDV)、阻力指数(RI)、搏动指数(PI)等指标,并监测血脂变化。结果与A组相比,B组颈动脉稳定斑块数量增多,斑块指数、IMT下降,PSV、EDV增快,RI、PI下降(P<0.05或P<0.01);B组患者低密度脂蛋白(LDL-C)浓度较治疗前有明显降低(P<0.01)。结论颈动脉超声检测可用于评估药物对ATCI患者的治疗作用。
Objective To determine the significance of high-frequency ultrasound（HFUS）in evaluating carotid artery plaques in the patients with atherosclerotic cerebral infarction（ATCI）treated by fluvastatin.Methods Sixty-eight patients with ATCI were divided into two groups of conventional treatment（group A）and fluvastatin treatment（group B,treated with additional fluvastatin 40mg/qn,po）.Carotid artery plaque index,intima-media thickness（IMT）,peak systolic velocity（PSV）,end diastolic velocity（EDV）,resistance index（RI）and pulsating index（PI）were detected before and after treating for 3 months.The serum lipids were examined as well.Results Compared to group A,the number of stable carotid artery plaques and IMT dercreased,PSV and EDV increased,but plaque index,RI,PI and LDL-C decreased in group B（P〈0.05 or P〈0.01）.Conclusion Carotid ultrasonography can be taken as an examination for evaluating therapeutic efficacy of drugs in the patients with ATCI.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第7期763-765,共3页
Jiangsu Medical Journal
关键词
高频超声
脑梗死
氟伐他汀
颈动脉斑块
High-frequency ultrasonography
Cerebral infarction
Fluvastatin
Carotid artery plaque
