摘要
目的探讨胃癌合并其他器官恶性肿瘤的发生率、临床病理特征、诊断、治疗和预后。方法回顾分析1996年1月至2007年12月复旦大学附属肿瘤医院外科治疗的74例胃癌合并其他器官原发癌患者的临床病理资料。结果本组74例患者占同期收治胃癌患者的1．7％。同时多原发癌10例：异时多原发癌64例．其中胃癌前异时多原发癌42例，胃癌后异时癌22例。共发生胃癌以外恶性肿瘤80个，以结直肠癌最多，占43．8％（35个），乳腺癌其次，占16．3％（13个）。异时癌的发生时问距胃癌诊断前后7-354（平均82．2）个月。胃癌诊断年龄33～84（平均61）岁。全组患者总的5年生存率为42．3％．其中同时多原发癌为15．2％．胃癌前异时多原发癌为42．9％．胃癌后异时癌为51_3％。36例死亡患者中，24例（66．7％）死于胃癌复发或转移，11例死于其他器官癌，1例死于肾脏衰竭。结论胃癌治疗时需注意同时并发其他器官原发癌的可能。胃癌合并其他器官原发癌患者的主要死凶可能是胃癌．
Objective To study the incidence, clinicopathological characteristics, diagnosis, treatment, and prognosis of synchronous or metachronous primary cancers in patients with gastric cancer. Methods Clinical data of 4426 patients with gastric cancer in our hospital from 1996 to 2007 were reviewed. Results Seventy-four（1.7%） patients had synchronous or metachronous primary cancer of other organ, of whom 10 were synchronous and 64 were metachronous. Colorectal cancer was the most common type of primary cancer in other organs（43.8%）, followed by breast cancer（16.3%）. The mean time interval between gastric cancer and metachronous primary cancer was 82.2（3-354） months. The mean age at the diagnosis of gastric cancer was 61.2（33-84） years. The 5-year overall survival rate was 42.3%. The 5-year survival rates in patients with synchronous cancer, pre-metachronous cancer or postmetachronous cancer were 15.2%, 42.9% and 51.3%, respectively. Causes of death were primary cancers of other organ in 11 patients, gastric cancer in 24, and renal failure in 1 patient. Conclusions Primary cancer of other organ should be considered in the management of gastric cancer. Aggressive treatment should be used for the second primary cancer. Gastric cancer is the main cause of death in these patients.
出处
《中华胃肠外科杂志》
CAS
北大核心
2010年第2期125-128,共4页
Chinese Journal of Gastrointestinal Surgery
关键词
胃肿瘤
肿瘤
多原发性
诊断
预后
Stomach neoplasms
Neoplasms, multiple primary
Diagnosis
Prognosis
