摘要
目的探讨原发性高血压(EH)患者血清基质金属蛋白酶9(MMP-9)与大动脉弹性的相关关系。方法选择EH患者119例,分为单纯高血压组59例,高血压合并颈动脉粥样硬化组(硬化组)60例;另选取同期我院体检健康者38例(对照组)。检测血压、身高、体质量、体质量指数(BMI)及生化指标。酶联免疫吸附法检测血清MMP-9水平,用超声心动图在主动脉瓣上3 cm处测量心脏收缩期和舒张期升主动脉内径,并计算出Peterson弹性指数(Ep)、僵硬度指数(β)、扩张性。结果对照组、单纯高血压组、硬化组的ln Ep(Ep的自然对数)、β、血清MMP-9依次升高;扩张性依次降低[(0.91±0.47)×10-6比(0.63±0.42)×10-6比(0.38±0.21)×10-6cm2/dyn,P<0.01]。偏相关分析显示,ln Ep、β与血清MMP-9呈正相关(r=0.43,P<0.01;r=0.44,P<0.01),扩张性与MMP-9呈负相关(r=-0.30,P<0.01)。多元逐步回归分析显示,血清MMP-9是大动脉弹性的独立影响因素之一。结论EH患者血清MMP-9的升高与大动脉弹性的减退有相关性。
Objective To investigate the association between serum matrix metalloproteinase-9（MMP-9） level and large arterial elasticity in patients with essential hypertension（EH）.Methods One hundred nineteen patients with EH were devided into two groups： 59 patients without atherosclerosis（EH group）,60 patients with carotic atherosclerosis（AS group）.Thirty-eight healthy volunteers were selected as controls.Blood pressure,body mass index（BMI） and other serum laboratory parameters were measured.Serum MMP-9 level was assessed by enzyme linked immunoassay.Diameters of ascending aorta 3 cm above the aortic valve were measured both in systolic and diastolic phase with M-mode echocardiography.Peterson elastic modulus（Ep）,aortic stiffness index（β） and distensibility of ascending aortic were calculated using formulas.Results Ln Ep,β and serum MMP-9 concentrations in control group,EH group and AS group were significantly increased progressively.Distensibility of ascending aorta in three groups was significantly decreased gradually [（0.91±0.47） ×10^-6 vs（0.63±0.42）×10^-6 vs（0.38±0.21）×10-6 cm^2/dyn,P〈0.01].Partial correlation analysis revealed that ln Ep,β were positively correlated with MMP-9（r=0.43,P〈0.01;r=0.44,P〈0.01） and distensibility was negatively correlated with MMP-9（r=-0.30,P〈0.01）.Multivariate regression analysis showed that serum MMP-9 level was one independent determinant of elasticity of large arteries in patients with EH.Conclusion There is a relationship between high serum MMP-9 level and decreased arterial elasticity.
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2010年第4期385-389,共5页
Chinese Journal of Hypertension
基金
江苏省自然基金资助项目(BK2008117)
关键词
高血压
基质金属蛋白酶
弹性
升主动脉
Hypertension
Matrix metalloproteinases
Elasticity
Ascending aorta
