摘要
目的评价美他环素联合新癀片治疗中、重度寻常痤疮的疗效与安全性。方法入选患者随机分为A组、B组和C组。A组口服盐酸美他环素胶囊0.2g,2次/d;新癀片1.28g,3次/d。B组口服盐酸美他环素胶囊0.2g,2次/d。C组口服盐酸米诺环素胶囊50mg,2次/d。三组患者同时外用维胺酯维E乳膏,每晚1次。疗程均为6周。于治疗前及治疗后第1、2、4和6周时分别计数皮损,观察疗效和不良反应。结果治疗2周和4周时,A组临床疗效均明显好于其他两组,差异有统计学意义(P<0.05);治疗结束时,各组均有75%以上的患者达到了基愈或显效,A组的有效率达到了90.1%。结论美他环素联合新癀片治疗寻常痤疮起效较快,疗效较好,耐受性良好。
Objective To evaluate the efficacy and safety of metacycline with xinhuangpian in the treatment of moderate to severe acne vulgaris. Method Erolled patients were divided into three groups randomly. The patients in group A was treated with metacycline hydrochloride （0.2g capsule, twice daily） .and xinhuangpin （1.28g, three daily ）, the patients in group B took metacycline hydrochloride （0.2g capsule, twice daily）only, the patients in group C took minocycline hydrochloride （50mg capsule, twice daily）only. All patients were topically treated with viaminate and vitamin E cream （each evening） . All treatment lasted for 6 weeks. The lesion amount, therapeutic effects and side effects were observed, before and after the treatment at 1,2, 4, 6 weeks. Results Clinical effective rates in group A were more higher than that in other two groups （ P 〈 0.05 ） after 2, 4 weeks treatment. More than 75% patients in each group improved their symptom greatly. Clinical effective rate in group A was 90.1% after 6 weeks treatment. Conclusion Metacycline with xinhuangpian in the treatment of moderate to severe acne has more immediate effects, more efficacy and less side effects than metacycline or minocycline.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2010年第4期335-336,共2页
The Chinese Journal of Dermatovenereology
