摘要
目的探讨在肝病患者血清中AFP水平的变化及临床意义。方法采用放射免疫分析对50例正常组和198例肝病组进行血清AFP水平的检测。结果急性肝炎、肝硬化伴腹水、原发性肝癌的患者治疗前血清AFP水平非常地高于正常组(P<0.01),后经治疗后AFP比治疗前有非常显著下降(P<0.01)。而慢性肝炎、肝硬化无腹水的患者血清AFP水平显著高于正常组(P<0.05)。肝血管瘤组的患者血清AFP水平与正常组比较无差异(P>0.05)。结论对血清中AFP的检测不仅能作为原发性肝癌的一个肿瘤标志物,而且是监测肝病活动的一个较好指标,对预后观察有重要的临床意义。
Objective To explore the change and the clinical significance of serum AFP levels in patients with lives diseases. Methods Serum AFP levels （with RIA） were determined in 198 patients with lives diseases controlled with 50 suhjetives. Result Before treatment, serum AFP in acute hepatitis, cirrhosis of lives especially in the patients developing ascites and primary hepatic carcinoma （PHC） were significantly higher than those in control （P〈0.01）. After treatment, serum AFP levels were significantly lower than that before treatment （P〈0.01）. Serum AFP levels in chronic hepatitis, cirrhosis of lives were than that in control （P〈0.05）. Serum AFP levels in hemangioms were not significantly different than that in control （P〉0. 05）. Conclusion Determination serum AFP levels is not only a tumor markers （TM） of PHC, but also a better monitoring role the progress of the lives diseases.
出处
《西部医学》
2010年第5期883-884,共2页
Medical Journal of West China
关键词
肝病
甲胎蛋白
放射免疫分析
Liver diseases
Alpha--fetoprotein （AFP）
Radioimmunoassay
