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血管内皮生长因子在原发性肝细胞肝癌中的表达及临床意义 被引量：1

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摘要 目的研究血管内皮生长因子(VEGF)在原发性肝细胞肝癌中的表达及临床意义。方法采用免疫组织化学SP法分析VEGF在原发性肝细胞肝癌中的表达。结果VEGF在肝癌组织中的阳性表达率(66.7%)显著高于在癌旁组织(39.1%)和正常肝组织中的阳性表达率(35.7%)(P<0.05);在高分化(8/17)、无肝内转移(16/29)、无淋巴转移(18/31)、无门静脉或胆道癌栓(18/30)、包膜完整(10/14)的肝癌中VEGF阳性表达率明显低于低分化(23/28)、有肝内转移(15/16)、有淋巴转移(13/14)、有门静脉或胆道癌栓(14/15)、包膜不完整(25/31)的肝癌病人(P<0.05)。结论VEGF可能是原发性肝细胞肝癌的生物学行为和预后的重要标记物,阳性表达者可能恶性程度高和预后不良。
作者 李秋萍 王双双
机构地区 长沙市第八人民医院
出处 《南华大学学报（医学版）》 2010年第1期74-76,共3页 Journal of Nanhua University(Medical Edition)
关键词 原发性肝细胞肝癌 血管内皮生长因子 表达 免疫组织化学
分类号 R735.7 [医药卫生—肿瘤]
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南华大学学报（医学版）
2010年 第1期

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