摘要
目的探讨血管内皮生长因子C(VEGF-C)及D2-40在结肠癌中的表达及临床意义。方法取85例人结肠癌组织样本,应用免疫组织化学法,检测VEGF-C及D2-40的表达,并与其临床特征作相关分析。结果85例结肠癌组织中VEGF-C阳性表达率(54.1%)及微淋巴管数量(LMVD)与正常结肠组织间差异有显著性意义,且与淋巴结转移和临床分期相关,而与患者的年龄、性别、大小、浸润深度和分化程度无关,VEGF-C的表达与LMVD呈正相关(r=0.543,P<0.05)。结论结肠癌中VEGF-C的高表达与淋巴管生成、淋巴结转移和预后有关,联合检测VEGF-C和D2-40的表达对判断结肠癌的早期淋巴道转移、预后及指导临床治疗有重要的意义。
Objective To approach the relationship between VEGF-C and D2-40 expressions in colon carcinoma and their association with clinicopathologic features.Methods The expressions of VEGF-C and D2-40 in 85 samples of colon cancer tissues were analyzed with immunohistochemistry. Results Of the 85 specimens,the positive expression of VEGF-C（54.1%） and Lymphatic vessel density（LMVD） were signifieantly higher than those in normal colonic tissues（P〈0.05）,and were correlated to lymph node metastasis and Duke＇s stage（P〈0.05） and non-correlated to age,sex,tumour size and the depth of invasion.While the expression of VEGF-C was positively correlated to the LMVD of the tumor（r=0.543,P〈0.05）.Conclusion The overexpresion of VEGF-C may be involved in generative of lympgatic vessel,nodal metastasis and prognosis.VEGF-C and D2-40 could serve as the joint detection of early clinical evaluation of lymphatic cancer metastasis as an important indicator and had important significance for the prognostic evaluation and treatment.
出处
《南华大学学报（医学版）》
2010年第1期70-73,共4页
Journal of Nanhua University(Medical Edition)
