摘要
目的探讨尿常规正常过敏性紫癜（HSP）患儿临床病理与预后关系。方法对我院2007年8月~2008年2月尿常规正常的HSP患儿12例做肾组织活检,常规送检光镜、电镜、免疫荧光,直接免疫荧光法检测肾组织呼吸道病毒,收集临床资料,随访6个月。结果12例患儿均存在肾脏损害,病理分级为Ⅰ~Ⅲa,以Ⅱb多见,肾组织以多种免疫复合物的沉积为主,6例肾组织中有病毒抗原。临床以单纯型为主,24h尿蛋白均正常,随访期本组患儿病情无恶化。结论尿常规正常HSP患儿临床以单纯型为主,早期存在肾脏损害,近期预后可能较好,需长期随访。
Objective To investigate the association between pathology and prognosis in children with Henoch-Schonlein Purpura and urinary normality.Methods Percutanous renal biopsy was performed on 12 HSP children with urinary normality,from August 2007 to February 2008.Renal tissue were delivered to be examed with light,electron and immunofluorescence microscope.Direct immunofluorescence assay was applied to assy respiratory viral antigens.Clinical data on the 12 children were collected.Six-month follow-up was done.Results Kidney damage was existed in all of the 12 children.Their hispathology was graded Ⅰ~Ⅲa,mostly Ⅱb.Deposition of immuncomplex in kidney is mainly various.The viral antigens in renal specimens were positive in 6 of 13.Main clinical type is merely purpura.24-hour urine protein is normal.After six months follow-up,patient′condition didn′t deteriorate.Conclusion In HSP children with urinary normality,main clinical type is merely purpura and there are kidney damage,their short-term prognosis might be fine,long-term follow-up is needed.
出处
《四川医学》
CAS
2010年第4期496-497,共2页
Sichuan Medical Journal
