摘要
终末期肝病是急性或慢性肝病的终末阶段,常伴有肝衰竭的临床表现。目前,原位肝移植术是治疗终末期肝病最有效的方法,虽然近期疗效较好,但因其成本高及排斥反应等不足使其临床广泛应用受到了一定的限制。干细胞是具有自我更新和多向分化潜能的细胞群体,研究显示干细胞可在特定条件下分化为肝细胞,且能支持受损肝脏的再生,在治疗终末期肝病中具有广阔的前景。
End stage liver disease is the end of acute or chronic liver diseases,with the manifestations of the liver failure.Liver transplantation is currently the only effective regimen.However,the application is limited due to its expensive costs and rejection.Stem cells are a cell colony with the feature of self-renewal and multi-directional differentiation.Experimenters have sought to use stem sells to generate large amounts of hepatocytes used in bioartificial livers or injected in vivo to repair the diseased organs.
出处
《医学综述》
2010年第9期1311-1313,共3页
Medical Recapitulate
关键词
干细胞
分化
肝细胞
终末期肝病
Stem cells
Differentiation
Hepatocyte
End stage liver disease
