摘要
目的研究奥氮平与氯氮平对脑电地形图(BEAM)的影响。方法对服用奥氮平与氯氮平的各30例精神分裂症患者,分别于治疗前及治疗后2、4、8周进行脑电地形图检查,采用简明精神病评定量表(BPRS)评定疗效。结果奥氮平组BEAM的表现为轻,中度异常,异常率为36.7%(11/30);氯氮平组BEAM的表现为轻、中、重度异常,异常率83.3%(25/30),2组患者的BEAM异常率有统计学差异(χ2=13.611,P<0.001)。BPRS减分率》50%的患者中,奥氮平组有6例出现BEAM异常,氯氮平组为16例,有统计学差异(χ2=8.925,P<0.01)。结论奥氮平与氯氮平治疗8周,均引起患者脑电地形图异常,奥氮平治疗组脑电地形图的异常率低于氯氮平治疗组。
Objective： To study differences of influence on brain electrical activity mapping（BEAM） between olanzipine and clozapine.Methods： 60 patients were divided equally into olanzapine and clozapine treatment groups and underwent BEAM topographic test before,and after 2,4 and 8 weeks of treatment.Efficacy was assessed using brief psychiatric rating scale（BPRS）.Results：Olanzapine group showed mild to moderate abnormality of BEAM,with abnormal rate of 36.7%.Clozapine group showed mild,moderate to severe abnormality of BEAM,with abnormal rate of 83.3%.There was significant difference between the two groups（P〈0.01）.Conclusion：Both olanzapine and clozapine treatment for 8 weeks cause abnormality in BEAM.Abnormal rate is lower in olanzapine group than in clozapine group.
出处
《上海精神医学》
2010年第2期100-101,共2页
Shanghai Archives of Psychiatry
关键词
奥氮平
氯氮平
脑电地形图
Olanzapine Clozapine Brain electrical activity mapping
