摘要
目的探讨事件相关电位视觉P300在血管性痴呆(VaD)患者认知功能评估中的价值。方法应用Nicolet脑诱发电位仪对39例VaD患者分别在多奈哌齐治疗前和治疗32周后进行视觉P300检测,并与34例健康老人作对照,使用简易精神状况检查(MMSE)评估患者的认知功能。结果治疗前VaD组MMSE[(16.4±3.9)分]分值显著低于健康对照组[(28.0±1.5)分]。视觉P300表现为P2、N2、P3靶刺激潜伏期延长,靶刺激P2、P3波幅低,非靶刺激P2波幅低。治疗后VaD患者认知功能改善,其视觉P300主要表现为P3潜伏期缩短,P3波幅增高。结论视觉P300有助于反映VaD患者认知功能的变化,P300这一指标的变化值得进一步跟踪随访。
Objective： To understand role of event-related potentials visual P300 in evaluation of cognitive function in vascular dementia（VaD）.Methods： With Nicolet instrument,visual P300 test and Mini-Mental State Examination（MMSE） assessment were carried out in 39 patients met NINCDS-AIREN criteria of VaD at baseline and after 32 weeks of treatment.34 healthy elderlies were also assessed as control group.Results：At baseline,MMSE score was lower in VaD patients than in control group（P〈0.01）.VaD patients had significantly delayed P2,N2 and P3 latencies and decreased P2 and P3 amplitudes in visual P300,compared with control group（P〈0.01）.After 32-week treatment,VaD patients demonstrated remarkably shortened P3 latency and increased P3 amplitude.Conclusion：Visual P300 indexes,especially P3 latency,might be useful in measuring cognitive function changes in VaD patients.
出处
《上海精神医学》
2010年第2期97-99,104,共4页
Shanghai Archives of Psychiatry
