摘要
目的评价氯氮平合并改良电抽搐治疗(MECT)难治性精神分裂症的临床疗效及安全性。方法将94例难治性精神分裂症患者按照就诊顺序分为两组,联合治疗组47例,在应用氯氮平的基础上合并MECT治疗,疗程8周;单药治疗组47例,仅给予氯氮平治疗。采用阳性与阴性症状量表(PANSS)及治疗中出现的症状量表(TESS)评定疗效和不良反应。结果联合治疗组的显效率为51.1%,单药治疗组的显效率为27.7%。联合治疗组不良反应较少。结论氯氮平合并改良电抽搐治疗难治性精神分裂症有效、安全。
Objective： To evaluate efficacy and safety of clozapine versus clozapine combined with MECT in the treatment of refractory schizophrenia.Methods： 94 patients with refractory schizophrenia were consecutively divided into combined group and single group,treated with clozapine solely or clozapine combined with MECT.Positive and Negative Syndromes Scale（PANSS） and Treatment Emergent Symptoms Scale（TESS） were used to evaluate efficacy and side effect.Results：Effective rate was 27.7% in clozapine group and 51.1% in combination group.Symptoms were significantly improved in combination group and side effects were less frequent in combination group.Conclusion：MECT augmented with clozapine has better efficacy and less side effects than clozapine monotherapy in the treatment of refractory schizophrenia.
出处
《上海精神医学》
2010年第2期95-96,114,共3页
Shanghai Archives of Psychiatry
关键词
改良电抽搐治疗
氯氮平
精神分裂症
Modified electroconvulsive therapy Clozapine Schizophrenia
