摘要
目的观察肝硬化患者消化性溃疡的特点,探讨小剂量普奈洛尔对肝源性溃疡(HU)愈合的影响。方法将该院2005年1月至2008年12月消化内科门诊及住院病例中明确诊断为HU患者121例随机分为治疗组(A组)61例及对照组(B组)60例。治疗组给予奥美拉唑20 mg(每天2次,4周)+甲硝唑400 mg(每天2次,2周)+阿莫西林1 000 mg(每天2次,2周)+普奈洛尔10 mg(每天3次,4周)。对照组(B组)给予奥美拉唑20 mg(每天2次,4周)+甲硝唑400 mg(每天2次,2周)+阿莫西林1 000 mg(每天2次,2周)。4周后随访,胃镜复查,确定症状缓解率及溃疡愈合情况。结果治疗4周后两组症状缓解率比较,差异无统计学意义(P>0.05)。两组胃镜复查溃疡愈合例数比较,差异有统计学意义(P<0.05)。结论小剂量普奈洛尔联合奥美拉唑三联疗法有助于HU的愈合。
Objective To observe the characteristics of digestive ulcer in liver cirrhosis patients and to discuss the influence of small dosage of propranolol on hepatogenic ulcer healing.Methods 121 cases of hepatogenic ulcer（HU） between January 2005 to December 2008 were randomly divided into two groups：the treatment group（A group,61 cases） and the control group（B group,60 cases）.The treatment group was given omeprazole 20 mg twice daily（4 weeks）＋metronidazole 400 mg twice daily（2 weeks）＋amoxicillin 1 000 mg twice daily（2 weeks）＋propranolol 10 mg 3 times daily（4 weeks）.The control group was given omeprazole 20 mg twice daily（4 weeks）＋metronidazole 400 mg twice daily（2 weeks）＋amoxicilin 1 000 mg twice daily（2 weeks）.After 4-week treatment,follow-up visit and gastroscope reexamination were performed.The symptom alleviation rate and ulcer healing status were evaluated and compared.Results The symptom alleviation rate after 4-week treatment had no statistical differenece between the two groups（P〉0.05）.The case number in ulcer healing by gastroscope reexamination had statistical differnece between the two groups（P〈0.05）.Conclusion Small dosage of propranolol combine with omeprazole triple therapy is helpful to hepatogenic ulcer healing.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第9期1104-1105,共2页
Chongqing medicine
