摘要
目的:考察了三种透皮促进剂对水溶性基质制剂脐中穴给药体外释药的影响,为脐中穴经皮给药新制剂适宜性提供参考。方法:制备不同浓度透皮吸收促进剂的水溶性基质制剂,选择小鼠腹部皮肤,采用Franz扩散池进行体外透皮实验,用高效液相色谱法测定接收液中指标成分芍药苷的含量。结果:透皮促进剂氮酮组对甘油明胶贴剂有显著的促透作用,水溶性氮酮3%时促透效果最好;二甲基亚砜促透作用不明显。结论:经皮吸收量与时间呈正相关性;透皮促进剂氮酮组与空白组比较,透过量均有显著性差异(P<0.05);其中水溶性氮酮组高于相应的脂溶性氮酮组。
Objective：To investigate the effects of the three types of penetration enhancers on the water-soluble matrix preparation navel hole in transdermal drug delivery point,for the navel hole in transdermal drug delivery formulations suitability of the new reference. Methods： Different concentrations of penetration enhancer of water-soluble matrix preparation,select the mouse abdominalskin,using Franz diffusion cell in vitro penetration experiments using highperformance liquid chromatography to receive fluid index constituents paeoniflorin. Results： The penetration enhancers Azone group glycerol gelatin patches significantly promote the role of permeability,water-soluble Azone 3 percent of pro-penetrating best; DMSO to promote penetration is not obvious. Conclusion： The percutaneous absorption was correlated with time; penetration enhancers Azone group and blank group,through the volume there are significant differences（P 0. 05）;in which water-soluble Azone group was higher than the corresponding fat-soluble Azone group.
出处
《中医药学报》
CAS
2010年第2期94-96,共3页
Acta Chinese Medicine and Pharmacology
基金
国家"十一五"科技支撑计划项目:现代制备技术在脐中穴经皮给药适宜性研究(编号:2006BAI09B08-10)
关键词
透皮促进剂
脐中穴经皮给药
体外透皮实验
Penetration enhancers
Navel hole in transdermal drug delivery
In vitro penetration test
