摘要
目的:探讨小剂量激素替代疗法对绝经后子宫体积和内膜厚度的影响。方法:利维爱组:54例患者口服利维爱1.25mg,1次/d,用药12～24个月。对照组:同期健康女性。应用阴道彩超测量子宫体积和内膜厚度,并对两组进行比较。结果:利维爱组与对照组的子宫体积分别为(24.56±7.64)、(21.02±11.08)cm3,无显著性差异(P>0.05)。两组子宫内膜厚度分别为(0.36±0.10)、(0.29±0.12)cm,比较有显著性差异(P<0.05)。结论:长期小剂量应用激素(利维爱)对子宫体积无显著影响,对子宫内膜厚度影响相对较大,故应定期监测,避免不良反应。
Objective： To explore the low-dose hormone replacement therapy on postmenopausal uterine volume and endometrial thickness. Methods： 54 cases of postmenopausal women were selected into Livial group, treated with tibolone, an oral dose of daily 1.25 mg, for 12 to 24 months. 46 cases of healthy women were chose as control group at the same period. Uterine volume and endometrial thickness measured with transvaginal color Doppler. Results： The uterine volume in Livial group and the control group were （24.56±7.64） cm^3, （21.02±11.08） cm^3 respectively, there was no significant difference （P〉0.05） between them. While endometrial thickness were （0.36±0.10） era, （0.29±0.12） cm respectively, which was thicker in Livial group than that in control group （P〈0.05）. Conclusion： Long-term low-dose steroid （Livial） had no significant influence on uterine volume, but has relatively large on the impact of endometrial thickness. It should be regularly monitored to avoid adverse reactions.
出处
《中国医药导报》
CAS
2010年第13期35-36,共2页
China Medical Herald
关键词
小剂量激素
替代疗法
子宫
Low-dose hormones
Replacement therapy
Uterus
