摘要
目的探讨舌下含服小剂量米索前列醇在无痛人流术中的作用。方法将120例早孕(6～8周)行无痛人工流产术者分成A组和B组各60例,均以丙泊酚2mg/kg诱导,加芬太尼1μg/kg,术中根据情况追加丙泊酚0.5～1mg/kg。A组术前不加其他药,B组于术前30分钟舌下含服米索前列醇0.2mg。观察两组术前、术中、术后的反应。结果 B组麻醉效果明显优于A组(优秀率93.33%VS53.33%,P<0.05),宫颈松弛率明显高于A组(87.50%VS6.67%,P<0.05),术前及术后子宫收缩好,术中出血量、手术时间、麻醉药用量及其不良反应与A组比较,差异均有统计学意义(P<0.01)。结论舌下含化小剂量米索前列醇配合丙泊酚复合芬太尼用于无痛人工流产,方法简便、安全、麻醉药用量少,术中出血少,适合门诊人流术开展。
Objective To observe the effect of low-dose sublingual misoprostol for painless artificial abortion. Methods One hundred and twenty early pregnancy women （6-8 weeks） treated with painless artificial abortion were randomly divided into two groups （ group A and group B）. They were all induced with Propofol （2 mg/kg ） plus Fentanyl （ 1 μg/kg）. During the operation, Propofol （0.5 - 1 mg/kg） was added depending on the situation. In group A, no drug was added before operation, while in group B misoprostol （0. 2 mg） was given by sublingual 30 minutes before operation. Women＇s reaction was observed before, during and after operation. Results Anesthesia effect in group B was excellent, which was significantly better than that in group A （93.33% VS 53. 33%, P 〈 0. 05）. The cervical relaxation rate in group B （87.50%） was significantly higher than that in group A （6. 67% ）. The uterus contraction of women in group B was good before and after operation. There were significant differences （P 〈0. 01 ） between group A and group B in intraoperative hemorrhage, operation time, dosage of anesthetics as well as adverse reactions. Conclusion It is simple and safe to use Propofol plus Fentanyl and combined with low-dose of misoprostol in painless artificial abortion, for less bleeding and less anesthetics. It is suitable to carry out in out-patient abortion.
出处
《实用医院临床杂志》
2010年第3期63-65,共3页
Practical Journal of Clinical Medicine
