摘要
目的研究根除幽门螺杆菌(HP)对长期服用非甾体抗炎药(NSAID)所致的消化性溃疡愈合和复发的影响。方法将116例长期服用NSAID所致的消化性溃疡患者分为HP阳性奥美拉唑组43例,HP阳性奥美拉唑加阿莫西林组38例,HP阴性奥美拉唑组35例,三组的用药时间均为6周。结果三组溃疡愈合率依次为65%、74%、71%(P>0.05)。追踪溃疡愈合者87例,并分为HP根除组26例,HP持续阳性组32例,HP持续阴性组29例。均停用抗溃疡药物,继续服用NSAID6个月后复查。累计溃疡复发率三组分别为31%、44%、29%(P>0.05)。结论根除HP不能提高NSAID相关消化性溃疡的愈合率,亦不能降低其复发率,且HP持续阳性者其溃疡复发率有升高趋势。
Objective To study the influence of eradicating helicobacter pylori（HP） on healing and recurrence of peptic ulcer cases with long-term use of nonsteroial antiinflammatory drug（NSAID）.Methods 116 peptic ulcer cases taking long-term NSAID were divided into omeprazole group of Hp positive reaction（n = 43,omeprazole 20mg,two times a day）,omeprazole plus amoxicillin group of Hp positive reaction（n = 38,omeprazole 20mg,two times a day;amoxicillin 0.5g,three times a day） and omeprazole group of Hp negative reaction（n =35,omeprazole 20mg,two times a day）.Results Ulcer healing rates in three groups were 65%,74%,71% respectively（P 0.05）.87 healed cases were divided into the eradicated Hp group（n = 26）,HP lasting positive reaction group（n = 32） and Hp lasting negative reaction group（n = 29）,and all the healed cases stopped peptic ulcer drug,but NSAID was taken continuously.73 cases were checked in 6 months,and u1cer recurrence rates in three healed groups were 31%,44%,29%,respectively（p 0.05）.Conclusion Eradicating Hp can neither improve the ulcer healing rates nor reduce the recurrence rates.But the ulcer recurrence rates of Hp lasting position reaction show a tendency to increase.
出处
《海南医学》
CAS
2010年第9期13-14,共2页
Hainan Medical Journal
关键词
非甾体抗炎药
消化性溃疡
幽门螺杆菌
奥美拉唑
Nonsteroial antiinflammatory Drug
Peptic ulcer
Helicobacter pylori1
Omeprazole
