摘要
为了分析2009年新型A型H1N1流感病毒分子流行病学的特点,本文从NCBI上下载不同分离宿主的流感毒株各节段全基因序列应用分子生物学软件进行遗传演化分析,结果显示:新型A(H1N1)流感毒株与过去的人源A(H1N1)毒株相比差异较大,相对于此前的人源A(H1N1)流感毒株,HA出现了79个位点发生突变。其中14个是相对于所有来源A(H1N1)流感毒株的新突变位点,但有37个突变位点只能在猪源毒株中找到。究竟这一现象说明新型A(H1N1)流感毒株是猪、人源毒株的重组变异毒株,还是猪源H1N1感染人群后逐渐变异并适应人群的结果,还有待进一步研究。
In order to analyze the molecular epidemiology of A（H1N1） influenza virus in 2009,the complete genome sequences of influenza strains from different host sources downloaded from the NCBI were analyzed on genetic evolution by DNAstar software in this research. The results showed that 79 mutation sites of new A（H1N1）influenza virus were observed compared to previous human A （H1N1） influenza strain,including 14 mutation sites new in all A （H1N1） influenza sources and 37 mutation sites only observed in swine strain. A significant difference was represented in antigenic sites between new A （H1N1） influenza strain and the previous human A （H1N1） strain. This phenomenon shows the new A （H1N1） influenza strain is either originated from the recombination of human and swine strain or from the infection in pig populations and gradual mutation to human tansmission,which remains to be further studied.
出处
《病毒学报》
CAS
CSCD
北大核心
2010年第2期88-96,共9页
Chinese Journal of Virology
关键词
甲型流感
序列
遗传演化分析
influenza A virus
sequence
genetic evolution analysis
