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抗血小板药物的遗传药理学研究进展 被引量：14

Advancement in the pharmacogenetics of antiplatelet drugs
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摘要 目前心脑血管疾病是导致人类死亡的主要病因,血小板的激活和聚集在其形成过程中起到核心作用。大量临床实践发现,不同个体对抗血小板药物的反应有着较大差异,有的患者甚至出现对这些药物产生抵抗的现象。研究表明,遗传因素是导致抗血小板药物疗效产生个体差异的重要原因之一。该综述概述了国内外对抗血小板药物在遗传药理学方面的最新研究进展。 Nowadays,cerebrovascular disease is one of the main causes of human death.Activation and aggregation of the platelet play core roles in the development of cerebrovascular diseases.A lot of clinical applications have showed that there are great interindividual differences in the response to antiplatelet drugs,and many patients have developed drug resistances.Pharmacogenetic studies have revealed that genetics is one of the key factors resulting in the interindividual differences of the response to antiplatelet drugs.In this overview,the newest advancement in pharmacogenetics is summarized with respect to the antiplatelet drugs.
作者 范岚 张伟 周宏灏
机构地区 中南大学临床药理研究所
出处 《中国药理学通报》 CAS CSCD 北大核心 2010年第4期421-424,共4页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30901834 30801421 30672497 30472054) 重大新药创制科技专项(No2009ZX09501-032) 教育部博士点青年教师基金资助项目(No20070533002) 国家新药研究重点实验室开放课题(NoSIMM0812KF-01) 湖南省科技计划资助项目(No2009SK3004 2009JT3020)
关键词 抗血小板药物 遗传药理学 单核苷酸多态性 阿司匹林 氯吡格雷 普拉格雷 antiplatelet drugs pharmacogenetics single nucleotide polymorphism aspirin clopidogrel prasugel
分类号 R05 [医药卫生] R331.124 [医药卫生—人体生理学]
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参考文献26

  • 1Mega J L,Close S L,Wiviott S D,et al.Cytochrome p450 polymorphisms and response to clopidogrel[J].N Engl J Med,2009,360(21):354-62.
  • 2Angiolillo D J.Variability in responsiveness to oral antiplatelet therapy[J].Am J Cardiol,2009,103(3 Suppl):27-43.
  • 3Halushka M K,Walker L P,Halushka P V.Genetic variation in cyclooxygenase 1:effects on response to aspirin[J].Clin Pharmacol Ther,2003,73(1):122-30.
  • 4Gurbel P A,Bliden K P,DiChiara J,et al.Evaluation of dose-related effects of aspirin on platelet function:results from the aspirin induced platelet effect(ASPECT)study[J].Circulation,2007,115(25):3156-64.
  • 5Maree A O,Curtin R J,Chubb A,et al.Cyclooxygenase-1 haplotype modulates platelet response to aspirin[J].J Thromb Haemost,2005,3(10):2340-5.
  • 6Gonza′lez-Conejero R,Rivera J,Corral J,et al.Biological assessment of aspirin efficacy on healthy individuals:heterogeneous response or aspirin failure[J]?Stroke,2005,36(2):276-80.
  • 7Papafili A,Hill M R,Brull D J,et al.Common promoter variant in cyclooxygenase-2 represses gene expression:evidence of role in acute-phase inflammatory response[J].Arterioscler Thromb Vasc Biol,2002,22(10):1631-6.
  • 8胡永芳,翟所迪,邱雯.CYP3A5^＊3和CYP3A4^＊18B基因多态性对肾移植患者环孢素药代动力学的影响[J].中国药理学通报,2009,25(3):378-382. 被引量：29
  • 9Angiolillo D J,Ferna′ndez-Ortiz A,Bernardo E,et al.Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel[J].Arterioscler Thromb Vasc Biol,2006,26(8):1895-900.
  • 10Lau W C,Gurbel P A,Watkins P B,et al.Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance[J].Circulation,2004,109(2):166-71.

二级参考文献19

  • 1成碟,徐为人,刘昌孝.细胞色素P450(CYP450)遗传多态性研究进展[J].中国药理学通报,2006,22(12):1409-1414. 被引量：44
  • 2Mahalati K, Belitsky P, Sketris I, et al. Neoral monitoring by simplified sparse sampling area under the concentration-time curve [J]. Transplantation, 1999 ,68( 1 ) :55 -62.
  • 3Evans W E, McLeod H L. Pharmacogenomics-Drug disposition, drug targets and side effects [ J ]. N Engl J Med, 2003,348 ( 6 ) : 538 - 49.
  • 4Weinshilboum R. Inheritance and drug response [ J ]. N Engl J Med, 2003,348(6) :529 -37.
  • 5Fukushima-Uesaka H, Saito Y, Watanabe H, et al. Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population[J]. Hum Mutat, 2004,23( 1 ) :100 -8.
  • 6Dai D, Tang J, Rose R, et al. Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos [ J ]. J Pharmacol Exp Ther, 2001,299 (3) :825 -31.
  • 7Chou F C, Tzeng S J, Huang J D. Genetic polymorphism of cytochrome P450 3A5 in Chinese [ J]. Drug Metab Dispos, 2001,29 (9) :1205 -9.
  • 8Kuehl P, Zhang J, Lin Y, et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression[J]. Nat Genet, 2001,27(4) :383 -91.
  • 9Hu Y F, Tu J H, Tan Z R, et al. Association of CYP3A4* 18B polymorphisms with the pharmacokinetics of cyclosporine in healthy subjects [ J ]. Xenobiotica, 2007,37 ( 3 ) :315 - 27.
  • 10Clase C M, Mahalati K, Kiberd B A, et al. Adequate early cyclosporin exposure is critical to prevent renal allograft rejection: patients monitored by absorption profiling [ J ]. Am J Transplant, 2002,2(8) :789 -95.

共引文献28

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引证文献14

二级引证文献107

中国药理学通报
2010年 第4期

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