摘要
目的:研究太子参正丁醇提取部位对急性心肌梗死后诱发实验性大鼠心肺损伤的保护作用。方法:采用大鼠左冠状动脉结扎复制急性心肌梗死模型,持续4周形成心肺损伤。血流动力学指标分析心功能;质量计算法分析心脏指数、左心室指数和肺指数;病理组织学分析左心室和肺病理改变;图像分析系统分析心肌梗死面积。结果:急性心肌梗死4周后,模型组大鼠心功能紊乱,心指数和肺指数增加,病理组织学分析证实左心室组织心肌细胞减少、成纤维细胞增生、炎细胞浸润,肺组织充血、水肿、炎细胞浸润,以上结果证实急性心肌梗死诱发心肺损伤病变模型成功。太子参正丁醇提取部位连续灌胃4周后,显著改善大鼠血流动力学指标,降低心指数和肺指数,减小心肌梗死面积,改善左心室和肺组织的病理学状态。结论:太子参正丁醇提取部位对急性心肌梗死诱发实验性心肺损伤大鼠具有一定的保护作用,该研究为太子参益气健脾、生津润肺的功效提供现代药理基础。
Objective：To investigate the ameliorated effects of n-butanol extract from Radix Pseudostellariae（RP） on rat experimental cardiopulmonary Injury induced by acute myocardial infarction.Methods：The experimental rat cardiac and lung injury was reproduced by acute cardiac infraction ligating left coronary artery for 4 weeks.Cardiac function were assayed by hemodynamics,heart index and lung index were detected by weighting,pathologic change was checked out by histophathology,and cardiac infarction size was assayed by image analysis system.Results：After operation 4 weeks,cardiac function was disturbed according to the results of hemodynamics.Cardiac and lung index,and cardiac infarction size was significantly increased in model group.Results of histopathology indicated that cardiac myocyte decrease,cardiac fibrosis functional disorder of the heart,increase of heart index and lun index,inflammatory cell infiltration,and pulmonary congestion and edema and so on indicated the model was succeed.Continued administration of n-butanol extract from RP for 4 weeks can remarkable ameliorate cardiac function,decrease the cardiac and lung index,and attenuate the heart failure pathological change.Conclusion：N-butanol extract from RP can alleviate rat cardiopulmonary injury induced by acute myocardial infarction.The present research provided the pharmacological base of replenishing qi for invigorating the spleen and promoting body fluid production for nourishing lung.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2010年第5期666-669,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
基金资助:国家自然科学基金(No.30701024)
贵州省科技攻关项目(No.黔科合S[2007]1035号)
贵州省科学技术基金(No.黔科合J字[2007]2133号)
江苏省博士后基金(No.0801026B)
江苏省中药药效与安全性评价重点实验室开发课题(No.P09003)~~
关键词
急性心肌梗死
太子参
大鼠
Acute myocardial infarction
Radix Pseudostellariae
Rats
