摘要
目的:比较瑞格列奈与阿卡波糖治疗2型糖尿病患者的临床疗效。方法:将120例单纯饮食运动治疗不满意的2型糖尿病患者随机分为瑞格列奈组60例(A组)和阿卡波糖60例(B组),疗程12周。测定并比较两组治疗前后空腹血糖(FPG)、餐后2小时血糖(2hPG),糖化血红蛋白(HbA1C),空腹及餐后胰岛素(FINS,P2hINS),血脂和体重指数(BMI)。结果:瑞格列奈组FBG平均下降3.84mmol·L-1,疗效优于阿卡波糖组(下降2.90mmol·L-1),两组P<0.01;两种药物对2hBG均有明显地降低作用(P<0.01),且降低程度相似;两组HbA1C均能显著降低,两组比较HbA1C降低的幅度无显著性差异(P>0.05);餐后2小时血清胰岛素与治疗前比较瑞格列奈组升高有显著性差异(P<0.01),而阿卡波糖组明显降低(P<0.01),治疗12周后瑞格列奈组BMI略上升1.3%(P>0.05),阿卡波糖组BMI降低2.6%(P<0.05),两组间比较有显著性差异(P<0.05)。阿卡波糖能使甘油三酯和低密度脂蛋白明显降低(P<0.01)。结论:瑞格列奈和阿卡波糖均能明显降低空腹和餐后血糖以及HbA1C。瑞格列奈降低空腹血糖的作用优与阿卡波糖,而阿卡波糖可减低餐后胰岛素分泌,调节血脂,减轻体重,更适合肥胖患者。
OBJECTIVE：To evaluate the efficacy of repaglinide vs.acarbose for type 2 diabetes mellitus.METHODS：After treatment failure with diet and exercise therapy alone,120 patients with type 2 diabetes mellitus were randomly assigned to receive either repaglinide（n = 60） or acarbose（n = 60） for 12 weeks.The values of fasting plasma glucose（FPG）,postprandial blood sugar（P2BG）,glycosylated hemoglobin（HbA1C）,fasting insulin（FINS）,postprandial insulin（P2hINS）,blood fat and body mass index（BMI） before and after treatment were measured and compared.RESULTS：The curative efficacy in repaglinide group was better than in acarbose group,with FBG decreased by an average of 3.84 mmol·L-1 vs.2.90 mmol·L-1（P 0.01）.The values of P2hBG in both group were reduced significantly after treatment（P 0.01）,and the reduction degree of the two groups was similar to each other.The levels of HbA1C in both groups were significantly decreased and no statistically significant difference were noted between the two groups（P 0.05）.The value of P2hINS in patients after treatment with repaglinide were significantly increased as compared with before treatment（P 0.01） but the value of P2hINS in acarbose group was decreased significantly as compared with before treatment（P 0.01）.At 12 weeks,BMI increased by 1.3%（P 0.05） in repaglinide group and decreased by 2.6%（P 0.05） in acarbose group,showing significant differences between the two groups（P 0.05）.Acarbose treatment significantly reduced both triglyceride and low density lipoprotein（P 0.01）.CONCLUSION：The values of FBG,P2hBG and HbA1C can all be decreased significantly by either Repaglinide or Acarbose.The effects of repaglinide is better than acarbose in down-regulating FBG;however,Acabose can down-regulating postprandial insulin secretion,regulating blood fat and lowering body weight,thus is more suitable for obese patients.
出处
《中国医院用药评价与分析》
2010年第4期359-361,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
2型糖尿病
瑞格列奈
阿卡波糖
餐后血糖
血脂
体重指数
Type 2 diabetes mellitus
Repaglinide
Acarbose
Postprandial blood glucose
Blood fat
Body mass index
