摘要
目的探讨熏烟对大鼠胫骨内种植体骨整合的影响。方法全麻下在32只Wistar大鼠右侧胫骨内植入纯钛螺纹状种植体,根据熏烟时间随机将其分为对照组、熏烟中止组和熏烟持续组,3个月后行X线片和骨密度测定。而后处死动物取胫骨标本,扫描电镜下观察各组种植体骨整合情况。实验数据以均数正负标准差表示,以SPSS13.0软件对数据行单因素方差分析。结果胫骨和种植体-骨界面平均密度值低,熏烟持续组与对照组间存在差异(F=6.808,P<0.05);X线片和扫描电镜下,熏烟持续组种植体-骨界面骨形成量少,矿化程度低,骨整合效果差。结论熏烟对大鼠胫骨种植体骨整合有负面作用。
Objective The aim of this study was to evaluate the influence of cigarette smoke inhalation（CSI） on the osteointegration of pure titanium implants in the tibiae bone of rats.Methods After anesthesia,a pure titanium implant was placed in the right tibia of each rat.According to the time of smoking,32 rats were randomly assigned to one of the following groups：Namely,the control group,smoking cessation group and continuous smoking group.3 months later,double energy X-ray absorptiometry and radiological observations were obtained.At the end of the experimental period,the animal were sacrificed,the tibiae were removed for the scanning electron microscope（SEM）.Statistical analysis was performed using SPSS 13.0 software package for one-way ANOVA.Results The results showed that continuous cigarette smoking promoted a significantly reduced bone density in the boneimplant area and tibiae（F=6.808,P0.05）.Poor osteointegration was obtained by X-ray and SEM.Conclusion Within in the limits of the present study,it can be concluded that cigarette smoke inhalation has a negative effect on osteointegration of implant inserted in rats.
出处
《国际口腔医学杂志》
CAS
2010年第2期146-149,153,共5页
International Journal of Stomatology
关键词
熏烟
种植体
骨整合
骨密度
cigarette smoke inhalation
implant
osteointegration
bone density
