摘要
目的探讨乙型肝炎肝硬化与HLA-DRB1*0701、DRB1*1301-2等位基因的关联性。方法采用聚合酶链反应-序列特应性引物(PCR-SSP)方法以健康人(39例)作对照,对吉林地区汉族32例慢性乙型肝炎患者和26例乙型肝炎肝硬化患者HLA-DRB1*0701、DRB1*1301-2等位基因进行了检测。结果慢性乙型肝炎组和乙型肝炎肝硬化组分别与健康对照组比较,发现慢性乙型肝炎组和乙型肝炎肝硬化组HLA-DRB1*0701等位基因频率明显高于健康对照组(10.9%vs 1.3%,13.5%vs 1.3%,P<0.05),DRB1*1301-2等位基因频率在3组间的差异无统计学意义(P>0.05)。结论 HLA-DRB1*0701等位基因与吉林地区汉族人与慢性乙型肝炎和乙型肝炎肝硬化相关,可能是慢性乙型肝炎、乙型肝炎肝硬化的易感基因。
Objective To investigate the association of human leucocyte antigen-DRB1 ＊ 0701, DRB1 ＊ 1301-2 alleles with chronic hepatitis B and hepatic cirrhosis in Han population of Jilin area. Methods HLA-DRB1 alleles in 32 patients with chronic hepatitis B, 26 patients with hepatic cirrhosis, 39 healthy controls were analyzed by using polymerase chain reaction-sequence specific primer technique. Results The frequency of HLA-DRB1 ＊ 0701 allele in chronic hepatitis B group and hepatic cirrhosis group was higher than that in healthy control group（10.9% vs 1; 3%, 13.5% vs 1.3%, P 〈0.05）. No significant differences in the frequencies of HLA-DRB1 ＊ 1301-2 alleles were observed among the three groups. Conclusion Alleles of HLA-DRB1 ＊ 0701 are closely associated with chronic hepatitis B and hepatic cirrhosis and may be susceptible genes or linkage genes of chronic hepatitis B.
出处
《临床荟萃》
CAS
2010年第9期777-779,共3页
Clinical Focus
关键词
肝炎
乙型
慢性
肝硬化
基因
多态性
单核苷酸
hepatitis B virus
hepatic cirhosis
genes
polymorphism, single nucleotide
