摘要
探讨肝癌肝动脉栓塞化疗后肿瘤的病理及某些分子生物学的变化。方法：从１９９２年１月到１９９７年１２月，结合临床对手术切除的原发性肝癌术前曾接受肝动脉栓塞化疗的１１７例标本作大体病理、镜下病理、免疫组化方法的肿瘤增殖细胞核抗原（ＰＣＮＡ），ｐ５３蛋白及抑癌基因ｐ５３ＰＣＲ技术的检测。结果：肉眼见坏死组织约占肿瘤体积不到５０％的有３２例，坏死占５０％～９０％的有５４例，９０％以上而有未完全坏死的有１８例，１００％的有１３例。镜下仍见有肿瘤细胞的有１１１例，全部为坏死组织而未见肿瘤细胞的有６例。肿瘤增殖细胞核抗原（ＰＣＮＡ）高指数的有７２例（６４９％），ｐ５３表达强阳性的有８５例（７６６％）。结论：本组资料表明，肝动脉栓塞化疗能使大部分肿瘤细胞坏死，但仅有极少部分全部坏死。
Objective: To observe the pathological and molecular changes of the primary liver carcinoma after chemoembolization. Methods: From June 1992 to December 1997,hepatectomy had been performed in 117 patients whom were treated with TACE before operation.Pathological study,PCNA and p53 assessment of these specimens had been done. Results:Only 5% cases displayed a complete tumor cell necrosis, 73% cases displayed a necrosis in more than of half of tumor cells.High labeling index of PCNA appeared in 64 9% and over expression of p53 protein in 76 6%,mutations of p53 alterations in 36% of the patients.Conclusion: TACE can cause the tumor cells necrosis completely.When the tumor cells were still alive,most of them were in proliferation active stage.
出处
《暨南大学学报（自然科学与医学版）》
CAS
CSCD
1998年第6期57-58,共2页
Journal of Jinan University(Natural Science & Medicine Edition)
