摘要
目的:通过Meta分析评价榄香烯治疗脑恶性肿瘤的近期疗效和1年生存率,并探讨榄香烯在治疗脑恶性肿瘤中的疗效。方法:通过中国知网、CBM、维普、万方以及Medline数据库,查找1980～2009年的相关文献,制定纳入和排除标准;通过Jadad量表评价纳入研究的质量,近期疗效按WHO规定的肿瘤疗效评价标准:完全缓解(CR),部分缓解(PR),稳定(NC),进展(PD)。有效=CR+PR,无效=NC+PD;利用RevMan4.2软件进行Meta分析。结果:入选5篇文献,共有患者351例。其中5篇均报道了近期疗效,171例进入治疗组,180例进入对照组。3篇文献报道了1年生存率,101例进入治疗组,105例进入对照组。对结果进行分析后认为,无论榄香烯单药治疗还是联合放疗均有一定疗效,并能提高1年生存率。结论:榄香烯治疗脑恶性肿瘤已显示出一定的疗效,但仍需要多中心大样本随机对照进一步验证此结果。
Objective： To evaluate the short-term effect of elemene treatment on malignant brain tumors and to analyze patients＇ 1-year survival rate using Meta-Analysis. Methods： We searched for related articles （1980-2009）in CNKI, CBM, VIP, Wanfang databases as well as the Medline database, and the standards of inclusion and exclusion were provided. The quality of the included study was evaluated by Jadad scale and the short-term effect was evaluated according to the response evaluation criteria in tumor provided by WHO： complete response （CR）, partial response （PR）, no change （NC）, and progressive disease （PD）. Efficacy was defined as CR/PR and inefficacy was defined as NC/PD. Revman 4.2 software was used for Meta-Analysis. Results： Five articles were adopted, and the total number of cases was 351. Short-term effect of Elemene was reported in five articles. There were 171 cases in the treatment group and 101 cases in the control group. Three articles reported 1-year survival rate. There were 101 cases in the treatment group and 105 cases in the control group. Elemene alone or combined with radiotherapy improved 1-year survival rate. Conclusion： Elemene is demonstrated effective in treating brain tumors, and it can be widely used. More series of controlled, perspective, randomized, double-blind, well-designed, and multi-center trials should be performed for further confirmation of the effect of Elemene on malignant brain tumors.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2010年第7期405-407,共3页
Chinese Journal of Clinical Oncology
