摘要
目的探讨血清总胆汁酸(TBA)、胆碱酯酶(CHE)联合测定在乙型肝炎诊断、鉴别、预示病情发展中的临床价值。方法256例乙型肝炎患者血清总胆汁酸测定采用循环酶法,胆碱酯酶测定用速率法,血清总胆红素(TBil)采用2,4-二氯苯胺重氮比色法测定,并加以比较。结果各型乙型肝炎患者TBA与正常对照比较显著增高(P<0.01),慢性肝炎中度组、重度组及原发性肝癌组分别与正常对照组比较,CHE显著降低;慢性肝炎随病情加重,TBA、TBil逐步增高,CHE逐步降低;重型肝炎TBA、TBil增高最为显著,与其他肝病组比较差异有统计学意义(P<0.01),CHE降低最为显著,与其他肝病组比较差异有统计学意义(P<0.01);TBA、TBil有良好的正相关性,与CHE有良好的负相关性。结论血清总胆汁酸、胆碱酯酶联合测定在乙型肝炎的诊断、鉴别、预示病情的发展具有极其重要的意义。
Objective This study investigates the clinical value of measuring total bile acid （TBA） and cholinesterase （CHE） simultaneously in the diagnosis,identification and prognosis of hepatitis B patients.Methods 256 hepatitis B patients were included in the study.TBA was measured by enzymatic cycling assay,cholinesterase was determined by rate method,and total bilirubin was determined by 2,4-Dichloroaniline diazonium chromatometry.The results were compared with healthy controls.Results TBA of hepatitis B patients was significantly higher than the healthy controls （P0.01）.The CHE level was significantly lower in moderate chronic hepatitis,severe hepatitis and primary liver cancer groups compared to healthy control group （P0.01）.With exacerbations of chronic hepatitis,TBA and TBil levels gradually increased,and CHE was gradually decreased most significantly in the severe hepatitis B group （P0.01）.TBA was positively correlated with TBil and negatively correlated with CHE.Conclusion Simultaneous determination of TBA and CHE is very important in the diagnosis,identification and prognosis of Hepatitis B patients.
出处
《临床肝胆病杂志》
CAS
2010年第2期187-188,共2页
Journal of Clinical Hepatology
