摘要
人体铁代谢几乎为“密闭性”的,不能有效排除过剩铁。输血依赖性贫血患者长期多次输血不可避免造成铁超负荷,游离铁沉积于肝脏、心脏及内分泌腺体等组织器官导致功能障碍,新近研究发现铁超负荷还能影响骨髓增生异常综合征等疾患本身的预后。临床医师应高度重视铁超负荷和铁毒性,对长期输血患者应定期筛查和监测铁负荷,及时开始去铁治疗,减轻铁毒性。
出处
《国际输血及血液学杂志》
CAS
2010年第2期168-171,共4页
International Journal of Blood Transfusion and Hematology
参考文献34
-
1Morrison ED,Brandhagen DJ,Phatak PD,et al.Serum ferritin level predicts advanced hepatic fibrosis among U.S.patients with phenotypic hemochromatosis.Ann Intern Med,2003,138(8):627-633.
-
2Crichton RR,Ward RJ.An overview of iron metabolism;molecular and cellular criteria for the selection of iron chelators.Curt Med Chem,2003,10(12):997-1004.
-
3Siah CW,Ombiga J,Adams LA,et al.Normal iron metabolism and the pathophysiology of overload disorders.Clin Bioehem Rev,2006,27(1):5-16.
-
4Oudit GY,Trivieri MG,Khaper N,et al.Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy.J Mol Med,2006,84(5):349-364.
-
5Kohgo Y,Ikuta K,Ohtake T,et al.Body iron metabolism and pathophysiology of iron overload,fat J Hematol,2008,88(1):7-15.
-
6Darbari DS,Kple-Faget P,Kwaguan J,et al.Circumstances of death in adult sickle cell disease patients.Am J Hematol,2006,81(11):858-863.
-
7Li CK,Chik KW,Lain CW,et al.Liver disease in transfusion dependent thalassaemia major.Arch Dis Chid,2002,86 (5):344-347.
-
8Wood JC,Enriquez C,Ghugre N,et al.Physiology and pathophysiology of iron cardiomyopathy in thalassemia.Ann N Y Acad Sci,2005,1054:386-395.
-
9Goldberg SL,Mody-Patel N,Chen E.Clinical and economic consequences of myeodysplastic syndromes in the United States:An Analysis of the Medicare Database.Blood (ASH Annual Meeting Abstracts),2008,112(11):636.
-
10Borgna-Pignatti C,Rugolotto S,De Stefano P,et al.Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine.Haematologica,2004,89 (10):1187-1193.
同被引文献31
-
1周国勇,胡森.去除白细胞血液输血对创伤后感染发生率的作用[J].中国危重病急救医学,2006,18(11):648-648. 被引量:1
-
2Rouault TA. Hereditary hemochromatosis. JAMA, 1993, 269: 3152- 3154.
-
3Fargion S, Fracanzani AL, Piperno A, et al. Prognostic factors for hepatocellular carcinoma in genetic hemochromatosis. Hepatology, 1994, 20: 1426-1431.
-
4Adams PC, Halliday JW, Powell LW. Early diagnosis and treatmentof hemochromatosis [ J ]. Adv Intern Med, 1989,34 : 111 -126.
-
5Bassett ML, Doran TJ,Halliday JW, et al. I Idiopathichemochromatosis : demonstration of homozygous-heterozygousmating by HLA typing of families[ J]. Hum Genet,1982,60(4):352-356.
-
6Crawford DH, Halliday JW, Summers KM, et al. Corcordance ofiron storage in siblings with genetichemochromatosis : evidence fora predorminandy genetic effecton iron storage [ J ] . Hepatology,1993,17(5):833-837.
-
7Pietrangelo A. Hemochromatosis [ J]. Gut,2003 , 52 ( Suppl 2 ):ii23-30.
-
8Pietrangelo A. Hereditary hemochromatosis-a new look at an olddisease [J].N Engl J Med,2004,350(23) :2383-2397.
-
9甄承恩.铁代谢异常肝病(血色病)研究进展[C].第12届华北五省市消化学术会议,2006.
-
10Tavill AS, American Association for the Study of Liver Diseases,American College of Gastroenterology. Diagnosis and managementof hemochromatosis[ J] . Hepatology ,2001,33 (5) ; 1321-1328.
引证文献3
-
1张国强,夏敏,郭继中,姚选军,杨树东.不典型原发性血色病1例[J].中华肝脏病杂志,2012,20(8):630-631. 被引量:1
-
2边丽颖,秦娟,刘红,常京平.一例少年血色病患者的护理[J].中华现代护理杂志,2014,20(32):4153-4155. 被引量:1
-
3陈文力.肿瘤患者输血与肿瘤发生发展关系的研究进展[J].医师在线,2025,15(2):84-86.
二级引证文献2
-
1方迎昕,于晓华,张涵祎,高思佳,单忠艳,滕晓春.铁超载继发糖尿病、性腺功能减退症1例[J].中华糖尿病杂志,2022,14(7):716-719.
-
2杨倩,查兵兵,李芸菲,丁和远,刘军.无铜蓝蛋白血症合并抗利尿激素分泌失调综合征1例报告[J].中国实用内科杂志,2024,44(8):698-701.
-
1Ruhl C.E.,Everhart J.E.,樊菁.服用咖啡和咖啡因降低了美国人血清丙氨酸转氨酶活性升高的风险[J].世界核心医学期刊文摘(胃肠病学分册),2005,0(5):15-16. 被引量:1
-
2何广胜,吴德沛,阮长耿.骨髓增生异常综合征的输血与铁超负荷[J].国际输血及血液学杂志,2009(5):385-388. 被引量:1
-
3张景瑞,张淑彦,肖娜.健康体检人群中甲状腺疾病筛查结果分析[J].中国农村卫生,2013(03Z):379-380.
-
4李忠,钟才云,王颖明,莫宝庆.具有抗氧化作用的维生素对高铁负荷大鼠抗氧化能力的影响[J].中国食品卫生杂志,2002,14(1):6-8. 被引量:5
-
5吴圣杰,王瑞,傅卓宁,陈海燕,刘重斌,董缪武.恬尔心和硝苯地平对慢性铁过负荷大鼠治疗效果的对比研究[J].毒理学杂志,2012,26(1):24-27.
-
6范敏华.静脉铁的临床应用[J].中国血液净化,2006,5(8):407-409. 被引量:26
-
7华平,李晓芬.卵巢保养,女人健康之本[J].家庭医药(快乐养生),2011(11):30-32.
-
8刘重斌,肖敏,吴博.硝苯地平对铁负荷大鼠营养代谢影响[J].中国公共卫生,2010,26(11):1402-1404. 被引量:1
-
9王振芳.住院输血患者HIV抗体检测分析[J].中华医院感染学杂志,2013,23(6):1282-1282.
-
10李兰霞.输血科医院感染危险因素与防护[J].中国医药指南,2009,7(6):116-117. 被引量:1