摘要
目的：研究原发和转移癌细胞的免疫表型特征及其与器官转移特异性的关系。方法：应用免疫组化和ＲＴ－ＰＣＲ检测了２２２例胃癌和甲状腺癌的６种免疫表型的表达。结果：ＣＤ４４Ｖ、ＡＦＰ、ＣＤ３４和Ｖｉｍｅｎｔｉｎ分别与癌细胞的淋巴结转移、肝转移、骨转移、腹膜或皮肤转移密切相关；临床应用这４种免疫表型预报癌转移发生部位的符合率分别是７５．０％、７５．０％、５７．１％和３７．５％。结论：癌细胞的侵袭转移存在着“归巢效应”。
Purpose To study the relationship between cancer cell immuno phenotype and metastatic organ specificity. Methods Immunohistochemistry and RT PCR were applicated to detect the expression of six markers in different primary and secondary cancers. Results A series of significant correlations were found between CD 44v and lymph node metastasis, AFP and liver metastasis, CD 34 and bone metastasis, vimentin and soft tissue metastasis. The coincidence of CD 44V ,AFP, CD 34 , vimentin in clinic practice were 75 0%, 75 0%, 57 1% and 37 5% respectively. Conclusion There is a “homing effect” in the invasion and metastasis of cancer cells. This is the key mechanism of cancer metastatic organ specificity.
出处
《临床与实验病理学杂志》
CAS
CSCD
1998年第5期417-419,I055,共4页
Chinese Journal of Clinical and Experimental Pathology
基金
全军青年科学基金
关键词
胃肿瘤
甲状腺肿瘤
肿瘤转移
免疫表型
分型
stomach neoplasms
thyroid neoplasms
neoplasm metastasis
immunophenotypeing
organ specificity
