摘要
目的：研究胃癌组织中生长抑素的表达及与淋巴结转移、预后、ＤＮＡ倍体的关系。方法：应用免疫组化及图像分析技术对１４０例各组织学类型胃癌中生长抑素（ＳＳ）的表达及ＤＮＡ倍体进行观察，并对其中１２７例患者进行随访。结果：３６例胃癌中检出ＳＳ阳性细胞（２５．７％）。ＳＳ的表达与分布特点、胃癌组织学类型、分化及淋巴结转移无明显关系，但与预后有明显关系，ＳＳ阳性胃癌组预后较好，较ＳＳ阴性胃癌组生存期长（Ｐ＜０．０１）。ＤＮＡ图像分析显示，与ＳＳ阴性胃癌组相比，ＳＳ阳性胃癌组的３～４Ｃ与５Ｃ细胞所占比例较大，＞５Ｃ细胞所占比例较小。结论：ＳＳ作为抑制因子不仅可抑制胃癌细胞的生长，而且含有ＳＳ细胞的胃癌患者生存期长，预后较好。推测胃癌中分泌的ＳＳ和其自身膜表面受体结合。
Purpose To sutdy the relationship between expression of somatostatin (SS) in gastric carcinoma (GC) and prognosis and DNA content. Methods Expressions of somatostatin (SS) in 140 cases of gastric carcinoma (GC) were observed by immunohistochemistry and DNA analysis. Among them, 127 cases were followed up. Results SS positive gastric carcinoma was demonstrated in 36 cases (257%). Expression of SS in GC was not related to histological types、 differentiation and metastasis of lymph nodes, but it was related to prognosis. The patients of SS positive GC were longer survived than SS negetive one GC (P<001). DNA analysis showed that there were more 3￣4 C、 5C cells and less >5C cells in SS positive group than in SS negetive group. Conclusions SS can inhibit growth of GC cells. The patients with SS positive GC cells have better prognosis.
出处
《临床与实验病理学杂志》
CAS
CSCD
1998年第1期23-25,I004,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
胃肿瘤
生长抑素
免疫组织化学
DNA倍体
stomach neoplasms
somatostatin
immunohistochemistry
DNA, neoplasms
ploidies
image interpretation, computerassisted
DNA ploidy
