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真菌鞘脂代谢及其与抗真菌药物关系研究进展 被引量：3

Progress in Fungi Sphingolipid Metabolism and Its Relationship with the Antifungi Drug Research
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摘要 鞘脂是真核细胞中普遍存在的成分,它在真核细胞的胞吞、胞饮、信号转导、细胞的生长、凋亡、分化、衰老等过程中起着非常重要的作用。该文论述了真菌鞘脂代谢的途径及参与其合成的相关酶和基因,并比较了真菌与哺乳动物鞘脂代谢途径的不同,旨在为研究新型无公害抗真菌药物提供理论依据。 Sphingolipid is ubiquitous of components of eukaryotic cell membranes,where it play important roles in intracellular endocytosis,endocytose,signaling transduction and in cell growth,apoptosis,differentiation,senescence,etc.The metabolism of fungi sphingolipid in the way of its synthesis was discussed in this article,included the relevant enzymes and genes,and compared the difference between fungi and mammals in the metabolism of sphingolipid,which provides theory for designding the new antifungal agents.
作者 郭星军 苟萍
机构地区 新疆大学生命科学与技术学院
出处 《生物技术》 CAS CSCD 北大核心 2010年第2期92-95,共4页 Biotechnology
基金 国家自然科学基金项目("灰葡萄孢菌肌糖磷脂酰神经酰胺合成酶基因功能和功能域研究" 30760131)资助
关键词 真菌 鞘脂 代谢 抗真菌药物 fungi sphingolipid metabolism antifungal drug
分类号 Q545 [生物学—生物化学]
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参考文献23

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同被引文献30

  • 1肖朝华,周建华,吴衡生.多球壳菌素对高糖诱导肾小球系膜细胞肥大及细胞外基质合成的影响[J].实用儿科临床杂志,2006,21(5):268-270. 被引量：20
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生物技术
2010年 第2期

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