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卵巢交界性肿瘤及伴微浸或局灶癌变88例临床分析 被引量:3

卵巢交界性肿瘤及伴微浸或局灶癌变88例临床分析
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摘要 目的探讨卵巢交界性肿瘤(borderline ovarian tumor,BOT)及伴微浸或局灶癌变的临床特点、病理类型、癌变潜能以及对血清CA125的敏感性。方法对2005年1月至2006年12月在天津市中心妇产科医院住院手术,术后病理确诊为卵巢交界性肿瘤及伴微浸或局灶癌变的88例进行分析,依据组织学诊断结果分为单纯BOT、BOT伴微浸以及BOT伴局灶癌变3组。结果发病年龄16~72岁,平均40.7岁,三组发病年龄比较无统计学意义(P>0.05)。75.0%(66/88)无临床症状,83.0%(73/88)肿物直径≥6cm。病理类型以卵巢交界性浆液性囊腺瘤或乳头状囊腺瘤为主占60.2%(53/88),交界性黏液性囊腺瘤占31.8%(28/88),交界性混合性囊腺瘤占4.5%(4/88),其他占3.4%(3/88)。88例中30例伴微浸,16例伴局灶癌变。在局灶癌变组中交界性浆液性囊腺瘤占3/4。BOT发生局灶癌变者与卵巢交界性浆液性囊腺瘤有较大的相关性,交界性浆液性肿瘤局灶癌变发生率明显高于黏液性肿瘤(P<0.05)。检测血清CA12579例,43例高于正常值,交界性肿瘤伴局灶癌变者血清CA125阳性率为(13/15)86.7%,交界性肿瘤伴微浸者阳性率为(18/26)69.2%,单纯交界性肿瘤阳性率为(12/38)31.6%。伴微浸及局灶癌变者对CA125的敏感性高于单纯BOT,有统计学意义(P<0.05)。1例术后18个月复发,术前血清CA125检测值在正常范围,术后病理仍为卵巢交界性浆液性乳头状囊腺瘤。结论卵巢交界性肿瘤具有低度恶性潜能,CA125对单纯BOT不敏感,术前诊断困难。育龄女性应定期行超声检查有无卵巢肿物,结合血清CA125检测可对BOT伴微浸以及伴局灶癌变者做术前预测诊断,积极尽早手术治疗,以减少癌变风险。
出处 《中国实用妇科与产科杂志》 CAS CSCD 北大核心 2010年第1期59-61,共3页 Chinese Journal of Practical Gynecology and Obstetrics
关键词 卵巢交界性肿瘤 低度恶性潜能 超声 CA125 borderline ovarian tumor low-grade malignant potential ultrasound CA125
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参考文献5

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