摘要
应用不同浓度人白细胞干扰素处理10例慢性乙型肝炎病人外周血淋巴细胞,观察病人姐妹染色单体互换(SCE)频率的动力学变化.结果表明,人白细胞干扰素处理组SCE平均频率明显低于对照组,差异高度显著(P<0.01);慢性迁延性肝炎和慢性活动性肝炎处理组之间SCE平均频率无显著性差异;但人白细胞干扰素处理低浓度组SCE平均频率低于高浓度组,差异不显著(P>0.05).提示人白细胞干扰素具有诱导HBV损伤人体DNA的修复作用;大剂量人白细胞干扰素对HBV损伤人体DNA的修复未必有益.
The peripheral lymphocytes from 10 chronic hepatitis B patients were treated with different concentrations of human α-interferon and dynamic changes of sister chromatid exchang (SCE) frequencies in peripheral lymphocytes of chronic hepatitis B patients were observed. The results obtained from the experiments showed that the groups treated with human α-interferon had a significantly higher mean SCE frequency than the control group (P<0.01) ; there was no significant difference in mean SCE frequency(P>0.05) between the group of chronic persistent hepatitis B and the group of chronic active hepatitis B treated with human α-interferon.
出处
《青岛医学院学报》
1990年第3期178-181,共4页
Acta Academiae Medicinae Qingdao Universitatis
关键词
干扰素
乙型肝炎
DNA损伤
修复
Men
Interferon type I
Hepatitis B
DNA virus infection
DNA repair
Chromatids
