摘要
目的探讨动脉灌注化疗联合后程加速超分割三维适形放疗晚期食管癌的临床应用。方法90例晚期食管癌患者随机分为单纯后程加速超分割三维适形放疗组(单放组)和动脉灌注化疗联合后程加速超分割三维适形放疗组(综合组),并在治疗后进行随访,观察临床及放射学改善情况,评价治疗效果。结果治疗后大部分患者临床指标及X线片表现明显改善,综合组X线Ⅰ级片率明显高于单放组。综合组1,2,3年生存率分别为68.9%、44.4%和35.6%,单放组1,2,3年生存率分别为46.7%、24.4%和15.6%,两组间生存率差异有显著性(P<0.05)。两组毒副作用相似,差异无显著性。结论动脉灌注化疗联合后程加速超分割三维适形放疗是治疗晚期食管癌的一种安全、可靠、疗效满意的治疗方法。
Objective To investigate the clinical effectiveness of arterial infusion chemotherapy combined with late-course hyperfractionated accelerated 3-dimensional conformal radiotherapy in treatment of advanced-stage esophageal carcinoma.Methods Ninety patients with advanced-stage esophageal carcinoma were randomly divided into two groups： group arterial infusion chemotherapy combined with late-course hyperfractionated accelerated 3-dimensional conformal radiotherapy and group pure radiotherapy.The patients were followed by regular visits to watch the clinical and radiological improvement and to evaluate therapeutic efficacy.Results The 1-,2-,and 3-year survival rates were 68.9%,44.4% and 35.6% in the combined therapy group,and were 46.7%,24.4% and 15.6% in purel radiotherapy group,with significant difference between the 2 groups（P0.05）.There was no marked difference in incidence rate of toxic reaction between the two groups.Conclusion Arterial infusion chemotherapy combined with late-course hyperfractionated accelerated 3-dimensional conformal radiotherapy is a safe,reliable and effective treatment for advanced-stage esophageal carcinoma.
出处
《中国肿瘤临床与康复》
2010年第2期146-148,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
食管肿瘤
动脉灌注化疗:后程加速超分割三维适形放疗
Esophageal neoplasms
Arterial infusion chemotherapy
Late-course hyperfractionated accelerated 3-dimensional conformal radiotherapy
