摘要
目的探讨肺硬化性血管瘤(sclerosing hemangioma of the lung,SHL)的临床病理特点及组织来源。方法对12例SHL进行临床病理及免疫组化研究。结果本组男2例,女10例,年龄35～65岁,平均45岁。HE染色示:SHL由实性片块区、乳头状区、血管瘤样区及硬化区4种组织结构组成。被覆乳头表面、实性区裂隙及血管样腔面的为立方细胞;实性区及乳头轴心为形态一致的圆形、多角形细胞。免疫组化:2种细胞均表达EMA和TTF-1,立方细胞表达CK;而多角形细胞弥漫表达Vimentin及ER、PR;瘤组织内散在有Syn、CgA、NSE阳性细胞区。结论 SHL多见于中青年女性,发病率低,易误诊为肺癌,熟悉本病的组织学特点对避免误诊有十分重要的意义。ER、PR的高表达可能与女性的高发病率密切相关。
Objective To investigate the chnic pathological characteristics and histogenesis of scleros- ing hemangioma of the lung（SHL）. Methods 12cases of SHL were studied by clinic pathology and immuno- histochemistry. Results 2cases of male and 10cases of female in this group. Their ages are from 35 to 65 years with the average of 45. HE staining revealed that SHL showed a mixture of the following four histological pat- terns： solid, papillary, hemangioma-like and sclerotic. Cuboidal cells covered the papillary projections and cleft-slide spaces in solid areas whereas solid areas and the stalk of papillary projections were composed of uni- form, round or polygonal ceils. Immunohistochemical staining revealed that both kinds of cells expressed EMA and TI＇F-1 ;the cuboidal cells expressed CK, and the polygonal pale cells expressed Vimentin, ER and PR with some of them showing positive for Syn, CgA and NSE. Conclusion Always seen among young and mid-aged wonen with low predisposition. It is often misdiagnosed as lung cancer. Being familiar with the charaiteristics of histology has great significance for avoiding misdiagnosing. Expression of ER,PR correlates with predisposition of this tumor to women.
出处
《中国现代药物应用》
2010年第8期175-176,共2页
Chinese Journal of Modern Drug Application
关键词
肺硬化性血管瘤
临床病理学
免疫组化
Sclerosing hemangioma of the lung
Clinical pathology
Immunohistochemistry
